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Apba1 amyloid beta precursor protein binding family A member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83589, updated on 19-Apr-2019

Summary

Official Symbol
Apba1provided by RGD
Official Full Name
amyloid beta precursor protein binding family A member 1provided by RGD
Primary source
RGD:620844
See related
Ensembl:ENSRNOG00000014928
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mint1
Summary
component of multimeric complex containing Munc18-1 and syntaxin; may mediate synaptic vesicle docking/fusion [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 141.5), Testes (RPKM 25.2) and 7 other tissues See more
Orthologs

Genomic context

See Apba1 in Genome Data Viewer
Location:
1q51
Exon count:
13
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (241594565..241796512)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (248875910..249079588)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554712 Neighboring gene protein prenyltransferase alpha subunit repeat containing 1 Neighboring gene family with sequence similarity 189, member A2 Neighboring gene uncharacterized LOC108349129 Neighboring gene tight junction protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
amyloid-beta binding IEA
Inferred from Electronic Annotation
more info
 
amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
PubMed 
gamma-aminobutyric acid secretion IEA
Inferred from Electronic Annotation
more info
 
gamma-aminobutyric acid secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
glutamate secretion IEA
Inferred from Electronic Annotation
more info
 
glutamate secretion ISO
Inferred from Sequence Orthology
more info
PubMed 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport ISO
Inferred from Sequence Orthology
more info
PubMed 
locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior ISO
Inferred from Sequence Orthology
more info
PubMed 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth ISO
Inferred from Sequence Orthology
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
PubMed 
synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynaptic active zone membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
amyloid-beta A4 precursor protein-binding family A member 1
Names
adapter protein X11alpha
amyloid beta (A4) precursor protein-binding, family A, APBA1: amyloid beta (A4) precursor protein-binding, family A, member 1 (X11)
amyloid beta (A4) precursor protein-binding, family A, member 1
mint-1
neuron-specific X11 protein
neuronal Munc18-1-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031779.2NP_113967.1  amyloid-beta A4 precursor protein-binding family A member 1

    See identical proteins and their annotated locations for NP_113967.1

    Status: PROVISIONAL

    Source sequence(s)
    AF029105
    UniProtKB/Swiss-Prot
    O35430
    Related
    ENSRNOP00000020123.4, ENSRNOT00000020123.4
    Conserved Domains (3) summary
    cd00992
    Location:747820
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01208
    Location:454625
    PTB_X11; X11-like Phosphotyrosine-binding (PTB) domain
    pfam00595
    Location:658741
    PDZ; PDZ domain (Also known as DHR or GLGF)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    241594565..241796512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    218575430..218778639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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