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Polr1a RNA polymerase I subunit A [ Rattus norvegicus (Norway rat) ]

Gene ID: 83581, updated on 12-Jan-2022

Summary

Official Symbol
Polr1aprovided by RGD
Official Full Name
RNA polymerase I subunit Aprovided by RGD
Primary source
RGD:620824
See related
Ensembl:ENSRNOG00000009545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rpa1; Rpo1-4
Summary
Contributes to DNA-directed 5'-3' RNA polymerase activity. Involved in rRNA transcription. Part of RNA polymerase I complex. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Spleen (RPKM 117.9), Adrenal (RPKM 93.4) and 9 other tissues See more
Orthologs
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Genomic context

See Polr1a in Genome Data Viewer
Location:
4q31
Exon count:
34
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (103950051..104014022)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99822964..99903969)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene inner membrane mitochondrial protein Neighboring gene small nucleolar RNA SNORD94 Neighboring gene Pentatricopeptide repeat domain 3 Neighboring gene hypothetical LOC100361613 Neighboring gene uncharacterized LOC120102169

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to DNA-directed 5'-3' RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase I activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase I activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase I complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase I complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase I subunit RPA1
Names
A194
DNA-directed RNA polymerase I A
DNA-directed RNA polymerase I largest subunit
DNA-directed RNA polymerase I subunit A
RNA polymerase 1-4
RNA polymerase I 194 kDa subunit
RNA polymerase I subunit A1
RPA194
polymerase (RNA) I polypeptide A
polymerase (RNA) I subunit A
NP_113960.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031772.2NP_113960.2  DNA-directed RNA polymerase I subunit RPA1

    Status: VALIDATED

    Source sequence(s)
    AF025425, JACYVU010000148
    Related
    ENSRNOP00000013587.2, ENSRNOT00000013587.3
    Conserved Domains (2) summary
    cd01435
    Location:161011
    RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain
    pfam04998
    Location:9651666
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    103950051..104014022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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