U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thbd thrombomodulin [ Rattus norvegicus (Norway rat) ]

Gene ID: 83580, updated on 24-Apr-2022

Summary

Official Symbol
Thbdprovided by RGD
Official Full Name
thrombomodulinprovided by RGD
Primary source
RGD:621299
See related
Ensembl:ENSRNOG00000004687 AllianceGenome:RGD:621299
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Involved in response to X-ray; response to cAMP; and response to lipopolysaccharide. Located in apicolateral plasma membrane; extracellular space; and vacuolar membrane. Used to study acute kidney failure. Biomarker of adult respiratory distress syndrome; hypertension; ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Thbd in Genome Data Viewer
Location:
3q41
Exon count:
1
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (135863366..135867018, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (142748673..142752325, complement)

Chromosome 3 - NC_051338.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101462 Neighboring gene somatostatin receptor 4 Neighboring gene CD93 molecule Neighboring gene uncharacterized LOC103691916

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within female pregnancy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of serine-type endopeptidase complex ISO
Inferred from Sequence Orthology
more info
 
located_in vacuolar membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thrombomodulin
Names
thrombomdulin

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031771.2NP_113959.1  thrombomodulin precursor

    See identical proteins and their annotated locations for NP_113959.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070903
    UniProtKB/TrEMBL
    O35370
    Related
    ENSRNOP00000006200.1, ENSRNOT00000006200.4
    Conserved Domains (5) summary
    pfam06247
    Location:346467
    Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
    pfam07645
    Location:324360
    EGF_CA; Calcium-binding EGF domain
    pfam09064
    Location:405438
    Tme5_EGF_like; Thrombomodulin like fifth domain, EGF-like
    pfam14670
    Location:244279
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl02432
    Location:30169
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051338.1 Reference mRatBN7.2 Primary Assembly

    Range
    135863366..135867018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)