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Thbd thrombomodulin [ Rattus norvegicus (Norway rat) ]

Gene ID: 83580, updated on 12-Aug-2018

Summary

Official Symbol
Thbdprovided by RGD
Official Full Name
thrombomodulinprovided by RGD
Primary source
RGD:621299
See related
Ensembl:ENSRNOG00000004687
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
cell surface glycoprotein; plays an important role in the protein C anticoagulant pathway [RGD, Feb 2006]
Orthologs

Genomic context

See Thbd in Genome Data Viewer
Location:
3q41
Exon count:
1
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (142748673..142752325, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (149159895..149163547, complement)

Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549662 Neighboring gene somatostatin receptor 4 Neighboring gene CD93 molecule Neighboring gene uncharacterized LOC103691915

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
female pregnancy ISO
Inferred from Sequence Orthology
more info
 
negative regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
response to X-ray IEP
Inferred from Expression Pattern
more info
PubMed 
response to cAMP IEP
Inferred from Expression Pattern
more info
PubMed 
response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
apicolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
vacuolar membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
thrombomodulin
Names
thrombomdulin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031771.2NP_113959.1  thrombomodulin precursor

    See identical proteins and their annotated locations for NP_113959.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070903
    UniProtKB/TrEMBL
    O35370
    Related
    ENSRNOP00000006200.1, ENSRNOT00000006200.3
    Conserved Domains (5) summary
    pfam06247
    Location:346467
    Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
    pfam07645
    Location:324360
    EGF_CA; Calcium-binding EGF domain
    pfam09064
    Location:405438
    Tme5_EGF_like; Thrombomodulin like fifth domain, EGF-like
    pfam14670
    Location:244279
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl02432
    Location:30169
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

    Range
    142748673..142752325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000071.1 Alternate Rn_Celera

    Range
    134707185..134710838 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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