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H3C2 H3 clustered histone 2 [ Homo sapiens (human) ]

Gene ID: 8358, updated on 7-Jun-2020

Summary

Official Symbol
H3C2provided by HGNC
Official Full Name
H3 clustered histone 2provided by HGNC
Primary source
HGNC:HGNC:4776
See related
Ensembl:ENSG00000286522 MIM:602819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H3/l; H3C1; H3C3; H3C4; H3C6; H3C7; H3C8; H3FL; H3C10; H3C11; H3C12; HIST1H3B
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Orthologs

Genomic context

See H3C2 in Genome Data Viewer
Location:
6p22.2
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (26031589..26032099, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26031817..26032288, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H4 clustered histone 1 Neighboring gene H4 clustered histone 2 Neighboring gene H2A clustered histone 4 Neighboring gene H2B clustered histone 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Hematologic neoplasm
MedGen: C0376545 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with HIST1H3B as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication-dependent nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
chromatin organization TAS
Traceable Author Statement
more info
 
chromatin silencing at rDNA TAS
Traceable Author Statement
more info
 
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of gene expression, epigenetic TAS
Traceable Author Statement
more info
 
nucleosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene silencing IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of megakaryocyte differentiation TAS
Traceable Author Statement
more info
 
telomere organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
nuclear nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H3.1
Names
H3 histone family, member L
histone 1, H3b
histone H3/l
histone cluster 1 H3 family member b
histone cluster 1, H3b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003537.4NP_003528.1  histone H3.1

    See identical proteins and their annotated locations for NP_003528.1

    Status: REVIEWED

    Source sequence(s)
    U91328
    Consensus CDS
    CCDS4573.1
    UniProtKB/Swiss-Prot
    P68431
    Related
    ENSP00000484841.1, ENST00000621411.2
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    26031589..26032099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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