U.S. flag

An official website of the United States government


Send to:

Choose Destination

H3C2 H3 clustered histone 2 [ Homo sapiens (human) ]

Gene ID: 8358, updated on 22-Sep-2022


Official Symbol
H3C2provided by HGNC
Official Full Name
H3 clustered histone 2provided by HGNC
Primary source
See related
Ensembl:ENSG00000286522 MIM:602819; AllianceGenome:HGNC:4776
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H3/l; H3C1; H3C3; H3C4; H3C6; H3C7; H3C8; H3FL; H3C10; H3C11; H3C12; HIST1H3B
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Try the new Gene table
Try the new Transcript table

Genomic context

See H3C2 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (26031589..26032099, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (25897545..25898055, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (26031817..26032327, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4264 Neighboring gene H4 clustered histone 2 Neighboring gene H2A clustered histone 4 Neighboring gene H2B clustered histone 3

Genomic regions, transcripts, and products


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


Associated conditions

Description Tests
Hematologic neoplasm
MedGen: C0376545 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag interacts with HIST1H3B as demonstrated by proximity dependent biotinylation proteomics PubMed
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in epigenetic regulation of gene expression IDA
Inferred from Direct Assay
more info
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
involved_in nucleosome assembly IMP
Inferred from Mutant Phenotype
more info
involved_in telomere organization TAS
Traceable Author Statement
more info

General protein information

Preferred Names
histone H3.1
H3 histone family, member L
histone 1, H3b
histone H3/l
histone cluster 1 H3 family member b
histone cluster 1, H3b

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003537.4NP_003528.1  histone H3.1

    See identical proteins and their annotated locations for NP_003528.1

    Status: REVIEWED

    Source sequence(s)
    Consensus CDS
    P68431, Q93081
    ENSP00000484841.2, ENST00000621411.3
    Conserved Domains (1) summary
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    26031589..26032099 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060930.1 Alternate T2T-CHM13v2.0

    25897545..25898055 complement
    GenBank, FASTA, Sequence Viewer (Graphics)