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Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83572, updated on 12-Jan-2022

Summary

Official Symbol
Pafah1b1provided by RGD
Official Full Name
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1provided by RGD
Primary source
RGD:620331
See related
Ensembl:ENSRNOG00000002755
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
LIS1
Summary
Enables dynein intermediate chain binding activity. Involved in several processes, including establishment of centrosome localization; generation of neurons; and negative regulation of neuron projection development. Located in several cellular components, including central region of growth cone; neuronal cell body; and nuclear envelope. Part of 1-alkyl-2-acetylglycerophosphocholine esterase complex and kinesin complex. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in lissencephaly and lissencephaly 1. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Brain (RPKM 940.0), Adrenal (RPKM 502.1) and 9 other tissues See more
Orthologs
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Genomic context

See Pafah1b1 in Genome Data Viewer
Location:
10q24
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59533042..59591808, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61456144..61577412, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit e, mitochondrial-like Neighboring gene clustered mitochondria homolog Neighboring gene U6 spliceosomal RNA Neighboring gene U2 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables dynein intermediate chain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule plus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables platelet-activating factor acetyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within acrosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ameboidal-type cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in auditory receptor cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in brain development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in brain morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
involved_in cerebral cortex neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
involved_in cochlea development ISO
Inferred from Sequence Orthology
more info
 
involved_in corpus callosum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in cortical microtubule organization ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of planar polarity of embryonic epithelium ISO
Inferred from Sequence Orthology
more info
 
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hippocampus development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within layer formation in cerebral cortex ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within maintenance of centrosome location ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization involved in establishment of planar polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule organizing center organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in microtubule organizing center organization ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule sliding IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nuclear membrane disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nuclear migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoclast development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular component organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in reelin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in reelin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in retrograde axonal transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within retrograde axonal transport ISO
Inferred from Sequence Orthology
more info
 
involved_in stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transmission of nerve impulse ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vesicle transport along microtubule ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of 1-alkyl-2-acetylglycerophosphocholine esterase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in astral microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
 
located_in central region of growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
part_of kinesin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
part_of microtubule associated complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in stereocilium ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
platelet-activating factor acetylhydrolase IB subunit alpha
Names
LIS-1
PAF acetylhydrolase 45 kDa subunit
PAF-AH 45 kDa subunit
PAF-AH alpha
PAF-AH beta
PAFAH alpha
lissencephaly-1 protein
platelet-activating factor acetylhydrolase beta subunit (PAF-AH beta)
NP_113951.1
XP_038942871.1
XP_038942872.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031763.3NP_113951.1  platelet-activating factor acetylhydrolase IB subunit alpha

    See identical proteins and their annotated locations for NP_113951.1

    Status: PROVISIONAL

    Source sequence(s)
    BC072510
    UniProtKB/Swiss-Prot
    P63004
    Related
    ENSRNOP00000003696.4, ENSRNOT00000003696.7
    Conserved Domains (3) summary
    cd00200
    Location:104408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:1034
    LisH

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    59533042..59591808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039086944.1XP_038942872.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:104408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:1034
    LisH
  2. XM_039086943.1XP_038942871.1  platelet-activating factor acetylhydrolase IB subunit alpha isoform X1

    Conserved Domains (3) summary
    cd00200
    Location:104408
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:111148
    7WD40; WD40 repeat [structural motif]
    pfam08513
    Location:1034
    LisH
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