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TOP1BETA DNA topoisomerase 1 beta [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835624, updated on 11-Oct-2018

Summary

Gene symbol
TOP1BETA
Gene description
DNA topoisomerase 1 beta
Primary source
Araport:AT5G55310
Locus tag
AT5G55310
Gene type
protein coding
RNA name
DNA topoisomerase 1 beta
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DNA topoisomerase 1 beta; DNA topoisomerase I alpha; MTE17.2; MTE17_2; TOP1; TOP1ALPHA; TOPOISOMERASE 1
Summary
Encodes one of two Arabidopsis type-I DNA topoisomerase I genes. Reducing the level of expression of this gene in a top1alpha (At5g55300) mutant background causes seedling lethality.

Genomic context

See TOP1BETA in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (22430105..22435134, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ATPase, V0 complex, subunit E Neighboring gene DNA topoisomerase I alpha Neighboring gene MBOAT (membrane bound O-acyl transferase) family protein Neighboring gene MBOAT (membrane bound O-acyl transferase) family protein

General gene information

Homology

  • Homologs of the TOP1BETA gene: The TOP1BETA gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.
  • Orthologs
NM_124913.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase type I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type I activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IC
Inferred by Curator
more info
PubMed 
chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISM
Inferred from Sequence Model
more info
 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DNA topoisomerase 1 beta
NP_200342.1
  • DNA topoisomerase 1 beta (TOP1BETA); FUNCTIONS IN: DNA topoisomerase type I activity; INVOLVED IN: DNA topological change; LOCATED IN: membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type (InterPro:IPR013030), DNA topoisomerase I, DNA binding, eukaryotic-type (InterPro:IPR008336), DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010); BEST Arabidopsis thaliana protein match is: DNA topoisomerase I alpha (TAIR:AT5G55300.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    22430105..22435134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124913.4NP_200342.1  DNA topoisomerase 1 beta [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200342.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FJ79
    Conserved Domains (4) summary
    smart00435
    Location:508884
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam01028
    Location:582778
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam02919
    Location:367579
    Topoisom_I_N; Eukaryotic DNA topoisomerase I, DNA binding fragment
    pfam14370
    Location:844909
    Topo_C_assoc; C-terminal topoisomerase domain
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