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TOP1ALPHA DNA topoisomerase I alpha [ Arabidopsis thaliana (thale cress) ]

Gene ID: 835623, updated on 12-Aug-2018

Summary

Gene symbol
TOP1ALPHA
Gene description
DNA topoisomerase I alpha
Primary source
Araport:AT5G55300
Locus tag
AT5G55300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
DNA topoisomerase 1 beta; DNA topoisomerase I alpha; MGO1; MGOUN 1; MTE17.1; MTE17_1; TOP1; TOP1BETA; TOPOISOMERASE 1
Summary
Encodes a type-I DNA topoisomerase I. Disruptions in this gene affect phyllotaxis and plant architecture suggesting that the gene plays a critical role in the maintenance of a regular pattern of organ initiation. Isolated as a protein oxidized during seed germination; proteomics approach revealed differences in de novo synthesis levels of this protein in condition with vs. without salicylic acid in the period from 0 to 40 hrs. following seed imbibition. Functions in stem cell maintenance at all stages of shoot and floral meristems and in the regulation of gene silencing.

Genomic context

See TOP1ALPHA in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (22424502..22429514, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene homolog of bacterial cytokinesis Z-ring protein FTSZ 1-1 Neighboring gene ATPase, V0 complex, subunit E Neighboring gene DNA topoisomerase 1 beta Neighboring gene MBOAT (membrane bound O-acyl transferase) family protein

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

NM_001203614.1
NM_001203615.1
NM_124912.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase type I activity IEA
Inferred from Electronic Annotation
more info
 
DNA topoisomerase type I activity IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA topoisomerase type I activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA topological change ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
chromatin remodeling IGI
Inferred from Genetic Interaction
more info
PubMed 
embryo development ending in seed dormancy IMP
Inferred from Mutant Phenotype
more info
PubMed 
flower morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
leaf morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
meristem structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
plant organ formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of meristem growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
shoot system morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISM
Inferred from Sequence Model
more info
 

General protein information

Preferred Names
DNA topoisomerase I alpha
NP_001190543.1
  • DNA topoisomerase I alpha (TOP1ALPHA); FUNCTIONS IN: protein binding, DNA topoisomerase type I activity; INVOLVED IN: in 8 processes; LOCATED IN: chromosome; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type (InterPro:IPR013030), DNA topoisomerase I, DNA binding, eukaryotic-type (InterPro:IPR008336), DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499); BEST Arabidopsis thaliana protein match is: DNA topoisomerase 1 beta (TAIR:AT5G55310.1).
NP_001190544.1
  • DNA topoisomerase I alpha (TOP1ALPHA); FUNCTIONS IN: protein binding, DNA topoisomerase type I activity; INVOLVED IN: in 8 processes; LOCATED IN: chromosome; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499); BEST Arabidopsis thaliana protein match is: DNA topoisomerase 1 beta (TAIR:AT5G55310.1).
NP_200341.1
  • DNA topoisomerase I alpha (TOP1ALPHA); FUNCTIONS IN: protein binding, DNA topoisomerase type I activity; INVOLVED IN: in 12 processes; LOCATED IN: chromosome; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: DNA topoisomerase I, DNA binding, mixed alpha/beta motif, eukaryotic-type (InterPro:IPR013030), DNA topoisomerase I, DNA binding, eukaryotic-type (InterPro:IPR008336), DNA topoisomerase I, C-terminal (InterPro:IPR001631), DNA topoisomerase I, active site (InterPro:IPR018521), DNA topoisomerase I, catalytic core, alpha/beta subdomain, eukaryotic-type (InterPro:IPR014727), DNA topoisomerase I, catalytic core, eukaryotic-type (InterPro:IPR013500), DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type (InterPro:IPR014711), DNA topoisomerase I, C-terminal, eukaryotic-type (InterPro:IPR013499), DNA breaking-rejoining enzyme, catalytic core (InterPro:IPR011010); BEST Arabidopsis thaliana protein match is: DNA topoisomerase 1 beta (TAIR:AT5G55310.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    22424502..22429514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_124912.5NP_200341.1  DNA topoisomerase I alpha [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_200341.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P30181
    Conserved Domains (4) summary
    smart00435
    Location:510886
    TOPEUc; DNA Topoisomerase I (eukaryota)
    pfam01028
    Location:585780
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:846911
    Topo_C_assoc; C-terminal topoisomerase domain
    cl02774
    Location:370582
    Topoisomer_IB_N; Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA ...
  2. NM_001203614.1NP_001190543.1  DNA topoisomerase I alpha [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4K3F4
    Conserved Domains (4) summary
    smart00435
    Location:510886
    TOPEUc; DNA Topoisomerase I (eukaryota)
    cd03489
    Location:370582
    Topoisomer_IB_N_LdtopoI_like; Topoisomer_IB_N_LdtopoI_like: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA (bacterial) and type IB ...
    pfam01028
    Location:585780
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:846910
    Topo_C_assoc; C-terminal topoisomerase domain
  3. NM_001203615.1NP_001190544.1  DNA topoisomerase I alpha [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190544.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4K3F5
    Conserved Domains (2) summary
    pfam01028
    Location:297428
    Topoisom_I; Eukaryotic DNA topoisomerase I, catalytic core
    pfam14370
    Location:494559
    Topo_C_assoc; C-terminal topoisomerase domain
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