U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Tdrd1 tudor domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 83561, updated on 8-Dec-2022

Summary

Official Symbol
Tdrd1provided by MGI
Official Full Name
tudor domain containing 1provided by MGI
Primary source
MGI:MGI:1933218
See related
Ensembl:ENSMUSG00000025081 AllianceGenome:MGI:1933218
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTR-1
Summary
Predicted to enable metal ion binding activity. Involved in gamete generation; gene silencing by RNA; and piRNA metabolic process. Located in chromatoid body and pi-body. Part of ribonucleoprotein complex. Is expressed in several structures, including reproductive system. Orthologous to human TDRD1 (tudor domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 23.7) and limb E14.5 (RPKM 0.9) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Tdrd1 in Genome Data Viewer
Location:
19; 19 D2
Exon count:
29
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (56814603..56858444)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (56826171..56870012)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32718 Neighboring gene rp1 MIF pseudogene Neighboring gene coiled-coil domain containing 186 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene actin filament associated protein 1-like 2 Neighboring gene predicted gene, 38597

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA methylation involved in gamete generation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA-mediated gene silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in piRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in pi-body IDA
Inferred from Direct Assay
more info
PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tudor domain-containing protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002238.2NP_001002238.1  tudor domain-containing protein 1

    See identical proteins and their annotated locations for NP_001002238.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AC125150, AC158549
    Consensus CDS
    CCDS29922.1
    UniProtKB/Swiss-Prot
    Q8K1G3, Q99MV1
    Related
    ENSMUSP00000107233.2, ENSMUST00000111606.8
    Conserved Domains (3) summary
    cd04508
    Location:760805
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:487606
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  2. NM_001002240.2NP_001002240.1  tudor domain-containing protein 1

    See identical proteins and their annotated locations for NP_001002240.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AC125150, AC158549
    Consensus CDS
    CCDS29922.1
    UniProtKB/Swiss-Prot
    Q8K1G3, Q99MV1
    Related
    ENSMUSP00000077785.5, ENSMUST00000078723.11
    Conserved Domains (3) summary
    cd04508
    Location:760805
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:487606
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  3. NM_001002241.2NP_001002241.1  tudor domain-containing protein 1

    See identical proteins and their annotated locations for NP_001002241.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AC125150, AC158549
    Consensus CDS
    CCDS29922.1
    UniProtKB/Swiss-Prot
    Q8K1G3, Q99MV1
    Related
    ENSMUSP00000107231.2, ENSMUST00000111604.2
    Conserved Domains (3) summary
    cd04508
    Location:760805
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:487606
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  4. NM_031387.3NP_113564.2  tudor domain-containing protein 1

    See identical proteins and their annotated locations for NP_113564.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
    Source sequence(s)
    AC125150, AK029806
    Consensus CDS
    CCDS29922.1
    UniProtKB/Swiss-Prot
    Q8K1G3, Q99MV1
    Related
    ENSMUSP00000112786.2, ENSMUST00000121249.8
    Conserved Domains (3) summary
    cd04508
    Location:760805
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    pfam00567
    Location:487606
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    56814603..56858444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527473.1XP_006527536.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527536.1

    Conserved Domains (2) summary
    pfam00567
    Location:718825
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  2. XM_006527478.1XP_006527541.1  tudor domain-containing protein 1 isoform X2

    Conserved Domains (2) summary
    pfam00567
    Location:718825
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  3. XM_006527475.4XP_006527538.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527538.1

    Conserved Domains (2) summary
    pfam00567
    Location:718825
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  4. XM_006527474.1XP_006527537.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527537.1

    Conserved Domains (2) summary
    pfam00567
    Location:718825
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  5. XM_006527476.2XP_006527539.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527539.1

    Conserved Domains (2) summary
    pfam00567
    Location:718825
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  6. XM_006527477.4XP_006527540.1  tudor domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527540.1

    Conserved Domains (2) summary
    pfam00567
    Location:718825
    TUDOR; Tudor domain
    pfam01753
    Location:163199
    zf-MYND; MYND finger
  7. XM_006527479.3XP_006527542.1  tudor domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    pfam00567
    Location:613720
    TUDOR; Tudor domain
    pfam01753
    Location:5894
    zf-MYND; MYND finger