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Tex14 testis expressed gene 14 [ Mus musculus (house mouse) ]

Gene ID: 83560, updated on 26-Sep-2022

Summary

Official Symbol
Tex14provided by MGI
Official Full Name
testis expressed gene 14provided by MGI
Primary source
MGI:MGI:1933227
See related
Ensembl:ENSMUSG00000010342 AllianceGenome:MGI:1933227
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein kinase binding activity. Involved in several processes, including intercellular bridge organization; mitotic spindle assembly checkpoint signaling; and nuclear division. Acts upstream of or within cellular response to leukemia inhibitory factor; negative regulation of cytokinesis; and negative regulation of protein binding activity. Located in intercellular bridge; kinetochore; and midbody. Is expressed in germ cell of ovary; germ cell of testis; ovary; and primordial germ cell of gonad. Human ortholog(s) of this gene implicated in spermatogenic failure 23. Orthologous to human TEX14 (testis expressed 14, intercellular bridge forming factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 6.6) and placenta adult (RPKM 0.2) See more
Orthologs
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Genomic context

See Tex14 in Genome Data Viewer
Location:
11; 11 C
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87295839..87446649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87405013..87555823)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1E (PP2C domain containing) Neighboring gene predicted gene, 33937 Neighboring gene predicted gene, 22883 Neighboring gene RAD51 paralog C Neighboring gene VISTA enhancer mm264 Neighboring gene uncharacterized LOC115487798 Neighboring gene predicted gene, 22068 Neighboring gene U1a1 small nuclear RNA Neighboring gene small nucleolar RNA, C/D box 3B1 Neighboring gene small nucleolar RNA, C/D box 3B3 Neighboring gene predicted gene, 23137 Neighboring gene small nucleolar RNA, C/D box 3B4 Neighboring gene small nucleolar RNA, C/D box 3B2 Neighboring gene predicted gene, 34000 Neighboring gene septin 4 Neighboring gene myotubularin related protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in attachment of spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in attachment of spindle microtubules to kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in intercellular bridge organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intercellular bridge organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in male meiotic nuclear division IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic sister chromatid separation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in intercellular bridge IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inactive serine/threonine-protein kinase TEX14
Names
testis-expressed protein 14
testis-expressed sequence 14 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199293.1NP_001186222.1  inactive serine/threonine-protein kinase TEX14 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).
    Source sequence(s)
    AL669902, BK000967
    UniProtKB/Swiss-Prot
    Q7M6U3
    Conserved Domains (5) summary
    COG0515
    Location:269632
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00204
    Location:39137
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:39131
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:6798
    ANK; ANK repeat [structural motif]
    cl21453
    Location:282519
    PKc_like; Protein Kinases, catalytic domain
  2. NM_031386.2NP_113563.2  inactive serine/threonine-protein kinase TEX14 isoform b

    See identical proteins and their annotated locations for NP_113563.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different first exon which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform b) has a shorter N-terminus when it is compared to isoform a.
    Source sequence(s)
    AL669902, BK000966
    Consensus CDS
    CCDS48877.1
    UniProtKB/Swiss-Prot
    Q7M6U3, Q99MV8
    Related
    ENSMUSP00000054444.6, ENSMUST00000060835.12
    Conserved Domains (5) summary
    COG0515
    Location:257620
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd00204
    Location:27125
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:27119
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:5586
    ANK; ANK repeat [structural motif]
    cl21453
    Location:270507
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    87295839..87446649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249327.3XP_011247629.1  inactive serine/threonine-protein kinase TEX14 isoform X1

    See identical proteins and their annotated locations for XP_011247629.1

    Conserved Domains (5) summary
    PTZ00322
    Location:72179
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    COG5214
    Location:458658
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    sd00045
    Location:5586
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270507
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017314856.2XP_017170345.1  inactive serine/threonine-protein kinase TEX14 isoform X3

    Conserved Domains (5) summary
    PTZ00322
    Location:72179
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    COG5214
    Location:458658
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    sd00045
    Location:5586
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270507
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017314855.2XP_017170344.1  inactive serine/threonine-protein kinase TEX14 isoform X2

    Conserved Domains (5) summary
    PTZ00322
    Location:72179
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    COG5214
    Location:458658
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    sd00045
    Location:5586
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270507
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017314857.2XP_017170346.1  inactive serine/threonine-protein kinase TEX14 isoform X4

    Conserved Domains (5) summary
    PTZ00322
    Location:72179
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    COG5214
    Location:458658
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    sd00045
    Location:5586
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270507
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017314858.2XP_017170347.1  inactive serine/threonine-protein kinase TEX14 isoform X7

    Conserved Domains (5) summary
    PTZ00322
    Location:72179
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    COG5214
    Location:458658
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    sd00045
    Location:5586
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:27119
    Ank_2; Ankyrin repeats (3 copies)
    cl21453
    Location:270507
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011249328.3XP_011247630.1  inactive serine/threonine-protein kinase TEX14 isoform X5

    See identical proteins and their annotated locations for XP_011247630.1

    Conserved Domains (2) summary
    COG5214
    Location:240440
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    cl21453
    Location:52289
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011249329.1XP_011247631.1  inactive serine/threonine-protein kinase TEX14 isoform X6

    See identical proteins and their annotated locations for XP_011247631.1

    Conserved Domains (2) summary
    COG5214
    Location:169369
    POL12; DNA polymerase alpha-primase complex, polymerase-associated subunit B [DNA replication, recombination, and repair]
    cl21453
    Location:7218
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001780081.2 RNA Sequence