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H3C12 H3 clustered histone 12 [ Homo sapiens (human) ]

Gene ID: 8356, updated on 21-Oct-2023

Summary

Official Symbol
H3C12provided by HGNC
Official Full Name
H3 clustered histone 12provided by HGNC
Primary source
HGNC:HGNC:4774
See related
Ensembl:ENSG00000197153 MIM:602817; AllianceGenome:HGNC:4774
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H3/j; H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3FJ; H3C10; H3C11; HIST1H3J
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H3C12 in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (27890315..27890826, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (27759966..27760477, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27858093..27858604, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27840874-27841511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24333 Neighboring gene H4 clustered histone 13 Neighboring gene HLA complex group 13 pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27856906-27857550 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27857551-27858195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:27858196-27858840 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27860089-27860632 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:27860633-27861176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24337 Neighboring gene H2A clustered histone 17 Neighboring gene H2B clustered histone 17

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables cadherin binding HDA PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleosome IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H3.1
Names
H3 histone family, member J
histone 1, H3j
histone H3/j
histone cluster 1 H3 family member j
histone cluster 1, H3j

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003535.3NP_003526.1  histone H3.1

    See identical proteins and their annotated locations for NP_003526.1

    Status: REVIEWED

    Source sequence(s)
    Z98744
    Consensus CDS
    CCDS4638.1
    UniProtKB/Swiss-Prot
    A0PJT7, A5PLR1, P02295, P02296, P16106, P68431, Q6ISV8, Q6NWP8, Q6NWP9, Q6NXU4, Q71DJ3, Q93081
    UniProtKB/TrEMBL
    A8K4Y7, B2R6Y1
    Related
    ENSP00000352252.3, ENST00000359303.4
    Conserved Domains (1) summary
    PTZ00018
    Location:1136
    PTZ00018; histone H3; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    27890315..27890826 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    27759966..27760477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)