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UCK1 uridine-cytidine kinase 1 [ Homo sapiens (human) ]

Gene ID: 83549, updated on 8-Jul-2021

Summary

Official Symbol
UCK1provided by HGNC
Official Full Name
uridine-cytidine kinase 1provided by HGNC
Primary source
HGNC:HGNC:14859
See related
Ensembl:ENSG00000130717 MIM:609328
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
URK1
Summary
This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]
Expression
Ubiquitous expression in kidney (RPKM 13.1), ovary (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

See UCK1 in Genome Data Viewer
Location:
9q34.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (131523801..131531263, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (134399188..134406650, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene proline rich coiled-coil 2B Neighboring gene uncharacterized LOC107987135 Neighboring gene uncharacterized LOC105376301 Neighboring gene protein O-mannosyltransferase 1 Neighboring gene proline rich transmembrane protein 1B Neighboring gene Rap guanine nucleotide exchange factor 1 Neighboring gene Sharpr-MPRA regulatory region 10461

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12255

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables uridine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in CTP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
uridine-cytidine kinase 1
Names
cytidine monophosphokinase 1
uridine monophosphokinase 1
NP_001129426.1
NP_001248379.1
NP_001248380.1
NP_001305448.1
NP_113620.1
XP_005272281.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135954.3NP_001129426.1  uridine-cytidine kinase 1 isoform b

    See identical proteins and their annotated locations for NP_001129426.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region which results in a frameshift and an early stop codon, compared to variant 1. This variant encodes isoform b which has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS48046.1
    UniProtKB/Swiss-Prot
    Q9HA47
    UniProtKB/TrEMBL
    A0A024R8E7
    Related
    ENSP00000361282.3, ENST00000372208.7
    Conserved Domains (2) summary
    COG0572
    Location:22169
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:25169
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  2. NM_001261450.3NP_001248379.1  uridine-cytidine kinase 1 isoform c

    See identical proteins and their annotated locations for NP_001248379.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, that results in a protein (isoform c) with a shorter N-terminus, compared to isoform c.
    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS59151.1
    UniProtKB/Swiss-Prot
    Q9HA47
    Related
    ENSP00000361284.3, ENST00000372210.7
    Conserved Domains (1) summary
    cd02023
    Location:28221
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  3. NM_001261451.3NP_001248380.1  uridine-cytidine kinase 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the 5' coding region, compared to variant 1, that result in a protein (isoform d) with a longer N-terminus, compared to isoform a.
    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS59152.1
    UniProtKB/Swiss-Prot
    Q9HA47
    Related
    ENSP00000361285.3, ENST00000372211.7
    Conserved Domains (2) summary
    COG0572
    Location:42237
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:42235
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  4. NM_001318519.2NP_001305448.1  uridine-cytidine kinase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in an internal exon, compared to variant 1. It encodes isoform e which is shorter than isoform a.
    Source sequence(s)
    AL358781
    UniProtKB/Swiss-Prot
    Q9HA47
    UniProtKB/TrEMBL
    A0A0S2Z5Y6
    Conserved Domains (2) summary
    COG0572
    Location:22209
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:25207
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
  5. NM_031432.5NP_113620.1  uridine-cytidine kinase 1 isoform a

    See identical proteins and their annotated locations for NP_113620.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the isoform a.
    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS6944.1
    UniProtKB/Swiss-Prot
    Q9HA47
    Related
    ENSP00000361289.4, ENST00000372215.5
    Conserved Domains (1) summary
    cd02023
    Location:25230
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RNA

  1. NR_134666.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) contains an alternate internal exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358781
    Related
    ENST00000491309.5
  2. NR_134667.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL358781

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    131523801..131531263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272224.2XP_005272281.1  uridine-cytidine kinase 1 isoform X1

    Conserved Domains (2) summary
    COG0572
    Location:22246
    Udk; Uridine kinase [Nucleotide transport and metabolism]
    cd02023
    Location:25244
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RNA

  1. XR_002956811.1 RNA Sequence

  2. XR_246602.4 RNA Sequence

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