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COG3 component of oligomeric golgi complex 3 [ Homo sapiens (human) ]

Gene ID: 83548, updated on 8-Jul-2021

Summary

Official Symbol
COG3provided by HGNC
Official Full Name
component of oligomeric golgi complex 3provided by HGNC
Primary source
HGNC:HGNC:18619
See related
Ensembl:ENSG00000136152 MIM:606975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC34
Summary
This gene encodes a component of the conserved oligomeric Golgi (COG) complex which is composed of eight different subunits and is required for normal Golgi morphology and localization. Defects in the COG complex result in multiple deficiencies in protein glycosylation. The protein encoded by this gene is involved in ER-Golgi transport.[provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in thyroid (RPKM 12.6), prostate (RPKM 12.2) and 25 other tissues See more
Orthologs
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Genomic context

See COG3 in Genome Data Viewer
Location:
13q14.13
Exon count:
24
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (45464916..45536701)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46039074..46110836)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 30 Neighboring gene SLC25A30 antisense RNA 1 Neighboring gene peptidylprolyl isomerase A pseudogene 25 Neighboring gene glutamate rich 6B Neighboring gene RNA, 5S ribosomal pseudogene 27 Neighboring gene TIMM9 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of component of oligomeric golgi complex 3 (COG3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
part_of Golgi transport complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Golgi transport complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cis-Golgi network IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in trans-Golgi network membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
conserved oligomeric Golgi complex subunit 3
Names
COG complex subunit 3
p94
tethering factor SEC34
vesicle-docking protein SEC34 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031431.4NP_113619.3  conserved oligomeric Golgi complex subunit 3

    Status: REVIEWED

    Source sequence(s)
    AL139326, AL606514
    Consensus CDS
    CCDS9398.1
    Related
    ENSP00000258654.8, ENST00000349995.10
    Conserved Domains (1) summary
    pfam04136
    Location:131274
    Sec34; Sec34-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    45464916..45536701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535267.3XP_011533569.1  conserved oligomeric Golgi complex subunit 3 isoform X2

    Conserved Domains (1) summary
    pfam04136
    Location:131274
    Sec34; Sec34-like family
  2. XM_011535266.2XP_011533568.1  conserved oligomeric Golgi complex subunit 3 isoform X1

    See identical proteins and their annotated locations for XP_011533568.1

    Conserved Domains (1) summary
    pfam04136
    Location:150
    Sec34; Sec34-like family

RNA

  1. XR_429222.4 RNA Sequence

  2. XR_001749695.2 RNA Sequence

  3. XR_001749696.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001204476.1: Suppressed sequence

    Description
    NM_001204476.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
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