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AIF1L allograft inflammatory factor 1 like [ Homo sapiens (human) ]

Gene ID: 83543, updated on 7-Jun-2020

Summary

Official Symbol
AIF1Lprovided by HGNC
Official Full Name
allograft inflammatory factor 1 likeprovided by HGNC
Primary source
HGNC:HGNC:28904
See related
Ensembl:ENSG00000126878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IBA2; C9orf58
Expression
Biased expression in kidney (RPKM 130.1), spleen (RPKM 121.3) and 8 other tissues See more
Orthologs

Genomic context

See AIF1L in Genome Data Viewer
Location:
9q34.12-q34.13
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (131096476..131123152)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (133971863..133998539)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene laminin subunit gamma 3 Neighboring gene LAMC3 intron enhancer-blocking element 9-5 Neighboring gene LAMC3 intron enhancer-blocking element 9-2 Neighboring gene RNA, U6 small nuclear 881, pseudogene Neighboring gene nucleoporin 214 Neighboring gene enhancer-blocking element 9-3 overlapping NUP214

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12783, MGC29466

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
colocalizes_with actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
allograft inflammatory factor 1-like
Names
ionized calcium binding adapter molecule 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185095.1NP_001172024.1  allograft inflammatory factor 1-like isoform 3

    See identical proteins and their annotated locations for NP_001172024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and it encodes the longest protein (isoform 3).
    Source sequence(s)
    AK128526, AL157938, BM975905, DA285481
    Consensus CDS
    CCDS55348.1
    UniProtKB/Swiss-Prot
    Q9BQI0
    Related
    ENSP00000361383.3, ENST00000372309.7
    Conserved Domains (1) summary
    cd00051
    Location:78138
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_001185096.1NP_001172025.1  allograft inflammatory factor 1-like isoform 4

    See identical proteins and their annotated locations for NP_001172025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate coding region segment and uses a different splice site which changes the reading frame, compared to variant 3. The resulting protein (isoform 4) is shorter and has a distinct C-terminus when it is compared to isoform 3.
    Source sequence(s)
    AL157938, BC021253, BM975905, DA285481
    Consensus CDS
    CCDS55349.1
    UniProtKB/Swiss-Prot
    Q9BQI0
    Related
    ENSP00000361374.1, ENST00000372300.5
    Conserved Domains (1) summary
    cl08302
    Location:5295
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_031426.4NP_113614.1  allograft inflammatory factor 1-like isoform 1

    See identical proteins and their annotated locations for NP_113614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate coding region segment, compared to variant 3. The resulting protein (isoform 1) is shorter when it is compared to isoform 3.
    Source sequence(s)
    AL157938, KF458943
    Consensus CDS
    CCDS6939.1
    UniProtKB/Swiss-Prot
    Q9BQI0
    Related
    ENSP00000247291.3, ENST00000247291.8
    Conserved Domains (1) summary
    cl08302
    Location:52112
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RNA

  1. NR_033701.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate coding segment and uses a different splice site in the 5' coding region which changes the reading frame, compared to variant 3. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057789, AL157938, BI766795, BM975905, DA285481
    Related
    ENST00000372314.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    131096476..131123152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015177.1XP_016870666.1  allograft inflammatory factor 1-like isoform X1

    Conserved Domains (1) summary
    cd00051
    Location:57117
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001002260.1: Suppressed sequence

    Description
    NM_001002260.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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