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Aifm1 apoptosis inducing factor, mitochondria associated 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83533, updated on 2-Nov-2024

Summary

Symbol
Aifm1provided by RGD
Full Name
apoptosis inducing factor, mitochondria associated 1provided by RGD
Primary source
RGD:620817
See related
EnsemblRapid:ENSRNOG00000006067 AllianceGenome:RGD:620817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aif; Pdcd8
Summary
Predicted to enable several functions, including FAD binding activity; NAD(P)H oxidase H2O2-forming activity; and poly-ADP-D-ribose binding activity. Involved in several processes, including cellular response to aldosterone; cellular response to estradiol stimulus; and cellular response to nitric oxide. Predicted to be located in cytosol and mitochondrial intermembrane space. Predicted to be active in mitochondrion and nucleus. Biomarker of middle cerebral artery infarction; retinal detachment; retinitis pigmentosa; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease X-linked recessive 4; X-linked deafness 5; and combined oxidative phosphorylation deficiency 6. Orthologous to human AIFM1 (apoptosis inducing factor mitochondria associated 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 413.4), Adrenal (RPKM 397.7) and 9 other tissues See more
Orthologs
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Genomic context

See Aifm1 in Genome Data Viewer
Location:
Xq36
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132528107..132567237, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127650223..127689356, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135304063..135343062, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene BCL6 co-repressor-like 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 3 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene RAB33A, member RAS oncogene family Neighboring gene zinc finger protein 280C Neighboring gene solute carrier family 25 member 14

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables FAD binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables FAD binding ISO
Inferred from Sequence Orthology
more info
 
enables FAD binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NAD(P)H oxidase H2O2-forming activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD(P)H oxidase H2O2-forming activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD(P)H oxidase H2O2-forming activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables NADH dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on NAD(P)H ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity, acting on NAD(P)H ISS
Inferred from Sequence or Structural Similarity
more info
 
enables poly-ADP-D-ribose binding ISO
Inferred from Sequence Orthology
more info
 
enables poly-ADP-D-ribose binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to aldosterone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to estradiol stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hydrogen peroxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to hypoxia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to nitric oxide IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial respiratory chain complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitochondrial respiratory chain complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial respiratory chain complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import into mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
involved_in protein import into mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of apoptotic DNA fragmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to L-glutamate IEP
Inferred from Expression Pattern
more info
PubMed 
NOT involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to ischemia IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to toxic substance IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
apoptosis-inducing factor 1, mitochondrial
Names
apoptosis-inducing factor 1, mitochondrial-like
apoptosis-inducing factor, mitochondrion-associated 1
programmed cell death 8 (apoptosis-inducing factor)
programmed cell death protein 8
NP_112646.1
XP_038956025.1
XP_038956026.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031356.2NP_112646.1  apoptosis-inducing factor 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_112646.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q548E3, Q9JM53
    UniProtKB/TrEMBL
    A6JMQ6, Q924M6
    Related
    ENSRNOP00000008503.3, ENSRNOT00000008503.7
    Conserved Domains (3) summary
    pfam14962
    Location:51124
    AIF-MLS; Mitochondria localization Sequence
    pfam07992
    Location:149461
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:464592
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    132528107..132567237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039100097.2XP_038956025.1  apoptosis-inducing factor 1, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A0G2K7K2, A6JMQ5, Q924M6
    Related
    ENSRNOP00000074241.1, ENSRNOT00000084848.3
    Conserved Domains (3) summary
    pfam14962
    Location:46120
    AIF-MLS; Mitochondria localization Sequence
    pfam07992
    Location:145457
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:460588
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term
  2. XM_039100098.2XP_038956026.1  apoptosis-inducing factor 1, mitochondrial isoform X2

    UniProtKB/TrEMBL
    Q924M6
    Conserved Domains (2) summary
    pfam07992
    Location:51363
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
    pfam14721
    Location:366494
    AIF_C; Apoptosis-inducing factor, mitochondrion-associated, C-term