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St3gal5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83505, updated on 15-Jan-2022

Summary

Official Symbol
St3gal5provided by RGD
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5provided by RGD
Primary source
RGD:620875
See related
Ensembl:ENSRNOG00000010284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Siat9
Summary
Predicted to enable lactosylceramide alpha-2,3-sialyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in salt and pepper syndrome. Orthologous to human ST3GAL5 (ST3 beta-galactoside alpha-2,3-sialyltransferase 5). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in Heart (RPKM 221.1), Spleen (RPKM 174.6) and 9 other tissues See more
Orthologs
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Genomic context

See St3gal5 in Genome Data Viewer
Location:
4q31
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (104134553..104192560)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (99937499..99999905)

Chromosome 4 - NC_051339.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102169 Neighboring gene uncharacterized LOC102556495 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102546367 Neighboring gene atonal bHLH transcription factor 8 Neighboring gene uncharacterized LOC120102309 Neighboring gene uncharacterized LOC120102308

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables lactosylceramide alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lactosylceramide alpha-2,3-sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables lactosylceramide alpha-2,3-sialyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables lactosylceramide alpha-2,3-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
involved_in sialylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lactosylceramide alpha-2,3-sialyltransferase
Names
CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase
GM3 synthase
ST3Gal V
ST3GalV
ganglioside GM3 synthase
sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase)
sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase)
NP_112627.2
XP_006236738.1
XP_006236739.1
XP_006236741.1
XP_006236742.1
XP_006236744.1
XP_006236746.1
XP_017448402.1
XP_038964364.1
XP_038964365.1
XP_038964366.1
XP_038964367.1
XP_038964369.1
XP_038964370.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398712.1NP_001385641.1  lactosylceramide alpha-2,3-sialyltransferase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000148
  2. NM_001398713.1NP_001385642.1  lactosylceramide alpha-2,3-sialyltransferase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000148
  3. NM_001398714.1NP_001385643.1  lactosylceramide alpha-2,3-sialyltransferase isoform 3

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000148
  4. NM_031337.3NP_112627.2  lactosylceramide alpha-2,3-sialyltransferase isoform 2

    See identical proteins and their annotated locations for NP_112627.2

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000148
    UniProtKB/Swiss-Prot
    Q68G12
    Related
    ENSRNOP00000042426.1
    Conserved Domains (1) summary
    pfam00777
    Location:115382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_174121.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000148

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051339.1 Reference mRatBN7.2 Primary Assembly

    Range
    104134553..104192560
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236680.2XP_006236742.1  lactosylceramide alpha-2,3-sialyltransferase isoform X4

    Conserved Domains (1) summary
    pfam00777
    Location:151323
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_006236676.2XP_006236738.1  lactosylceramide alpha-2,3-sialyltransferase isoform X1

    Related
    ENSRNOP00000072818.2, ENSRNOT00000078793.2
    Conserved Domains (1) summary
    pfam00777
    Location:142409
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_006236677.2XP_006236739.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    UniProtKB/Swiss-Prot
    Q68G12
    Conserved Domains (1) summary
    pfam00777
    Location:115382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_017592913.2XP_017448402.1  lactosylceramide alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:58325
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_039108438.1XP_038964366.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:115382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. XM_039108441.1XP_038964369.1  lactosylceramide alpha-2,3-sialyltransferase isoform X5

    Conserved Domains (1) summary
    pfam00777
    Location:58325
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. XM_006236682.2XP_006236744.1  lactosylceramide alpha-2,3-sialyltransferase isoform X5

    See identical proteins and their annotated locations for XP_006236744.1

    Conserved Domains (1) summary
    pfam00777
    Location:58325
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. XM_006236684.4XP_006236746.1  lactosylceramide alpha-2,3-sialyltransferase isoform X5

    See identical proteins and their annotated locations for XP_006236746.1

    Conserved Domains (1) summary
    pfam00777
    Location:58325
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. XM_039108442.1XP_038964370.1  lactosylceramide alpha-2,3-sialyltransferase isoform X6

    Conserved Domains (1) summary
    pfam00777
    Location:15282
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  10. XM_006236679.4XP_006236741.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    See identical proteins and their annotated locations for XP_006236741.1

    UniProtKB/Swiss-Prot
    Q68G12
    Conserved Domains (1) summary
    pfam00777
    Location:115382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  11. XM_039108436.1XP_038964364.1  lactosylceramide alpha-2,3-sialyltransferase isoform X2

    Conserved Domains (1) summary
    pfam00777
    Location:125392
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  12. XM_039108437.1XP_038964365.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Conserved Domains (1) summary
    pfam00777
    Location:115382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  13. XM_039108439.1XP_038964367.1  lactosylceramide alpha-2,3-sialyltransferase isoform X3

    Related
    ENSRNOP00000082302.1, ENSRNOT00000115948.1
    Conserved Domains (1) summary
    pfam00777
    Location:115382
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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