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Kl Klotho [ Rattus norvegicus (Norway rat) ]

Gene ID: 83504, updated on 2-Oct-2018

Summary

Official Symbol
Klprovided by RGD
Official Full Name
Klothoprovided by RGD
Primary source
RGD:620396
See related
Ensembl:ENSRNOG00000001092
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
may be involved in suprresion of aging phenotypes [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 1010.8) See more
Orthologs

Genomic context

Location:
12p12
Exon count:
5
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (942974..987206)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (929158..972144)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548900 Neighboring gene bolA-like protein 2 pseudogene Neighboring gene uncharacterized LOC102548964 Neighboring gene StAR-related lipid transfer domain containing 13 Neighboring gene uncharacterized LOC108352405

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
beta-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-glucuronidase activity IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acute inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
aging ISO
Inferred from Sequence Orthology
more info
 
aging TAS
Traceable Author Statement
more info
PubMed 
calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
energy reserve metabolic process IEA
Inferred from Electronic Annotation
more info
 
energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
 
fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
norepinephrine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
response to fibroblast growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031336.1NP_112626.1  klotho precursor

    See identical proteins and their annotated locations for NP_112626.1

    Status: PROVISIONAL

    Source sequence(s)
    AB017820
    UniProtKB/Swiss-Prot
    Q9Z2Y9
    Related
    ENSRNOP00000001449.2, ENSRNOT00000001449.4
    Conserved Domains (1) summary
    cl23725
    Location:59508
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    942974..987206
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    2195730..2234485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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