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Kl Klotho [ Rattus norvegicus (Norway rat) ]

Gene ID: 83504, updated on 3-May-2022

Summary

Official Symbol
Klprovided by RGD
Official Full Name
Klothoprovided by RGD
Primary source
RGD:620396
See related
Ensembl:ENSRNOG00000001092 AllianceGenome:RGD:620396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable fibroblast growth factor binding activity and fibroblast growth factor receptor binding activity. Involved in several processes, including norepinephrine biosynthetic process; response to angiotensin; and response to vitamin D. Predicted to be located in membrane. Used to study familial hyperlipidemia; hypertension; and kidney failure. Biomarker of chronic kidney disease (multiple); hypertension; retinitis pigmentosa; secondary hyperparathyroidism; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 1010.8) See more
Orthologs
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Genomic context

Location:
12p12
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (490402..531417)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (942974..987206)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548900 Neighboring gene bolA-like protein 2 pseudogene Neighboring gene uncharacterized LOC102548964 Neighboring gene StAR-related lipid transfer domain containing 13 Neighboring gene transfer RNA proline (anticodon AGG)

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-glucuronidase activity IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acute inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within aging ISO
Inferred from Sequence Orthology
more info
 
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in aging TAS
Traceable Author Statement
more info
PubMed 
involved_in calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in energy reserve metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within energy reserve metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of bone mineralization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to activity IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to angiotensin IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to fibroblast growth factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to vitamin D IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
klotho
NP_112626.1
XP_038945736.1
XP_038945737.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031336.2NP_112626.1  klotho precursor

    See identical proteins and their annotated locations for NP_112626.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000223
    UniProtKB/Swiss-Prot
    Q9Z2Y9
    Related
    ENSRNOP00000001449.3, ENSRNOT00000001449.5
    Conserved Domains (1) summary
    cl23725
    Location:59508
    Glyco_hydro_1; Glycosyl hydrolase family 1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    490402..531417
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089808.1XP_038945736.1  klotho isoform X1

    Conserved Domains (1) summary
    cl23725
    Location:283719
    Glyco_hydro; Glycosyl hydrolases
  2. XM_039089809.1XP_038945737.1  klotho isoform X2

    Conserved Domains (1) summary
    cl23725
    Location:210646
    Glyco_hydro; Glycosyl hydrolases