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SLD5 DNA replication protein-like protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834960, updated on 6-Oct-2023

Summary

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Gene symbol
SLD5
Gene description
DNA replication protein-like protein
Primary source
Araport:AT5G49010
Locus tag
AT5G49010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
EMB2812; EMBRYO DEFECTIVE 2812; K19E20.14; K19E20_14; SYNTHETIC LETHALITY WITH DPB11-1 5
Summary
Similar to the SLD5 component of GINS complex, which in other organism was shown to be involved in the initiation of DNA replication.
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Genomic context

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Location:
chromosome: 5
Exon count:
5
Sequence:
Chromosome: 5; NC_003076.8 (19866231..19868877)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene Galactose oxidase/kelch repeat superfamily protein Neighboring gene uncharacterized protein Neighboring gene protein arginine methyltransferase 4A Neighboring gene tRNA synthetase class I (I, L, M and V) family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide analysis of the core DNA replication machinery in the higher plants Arabidopsis and rice. Shultz RW, et al. Plant Physiol, 2007 Aug. PMID 17556508, Free PMC Article
  2. Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Zhou Y, et al. Proc Natl Acad Sci U S A, 2017 May 2. PMID 28428341, Free PMC Article
  3. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
  4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001125927.2
NM_124278.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication initiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GINS complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
DNA replication protein-like protein
NP_001119399.1
  • SYNTHETIC LETHALITY WITH DPB11-1 5 (SLD5); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: DNA-dependent DNA replication initiation; LOCATED IN: GINS complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: GINS complex, subunit Sld5 (InterPro:IPR008591), GINS complex (InterPro:IPR021151); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_199712.2
  • SYNTHETIC LETHALITY WITH DPB11-1 5 (SLD5); CONTAINS InterPro DOMAIN/s: GINS complex (InterPro:IPR021151), GINS complex, subunit Sld5 (InterPro:IPR008591); Has 338 Blast hits to 337 proteins in 171 species: Archae - 0; Bacteria - 0; Metazoa - 117; Fungi - 122; Plants - 54; Viruses - 0; Other Eukaryotes - 45 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    19866231..19868877
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001125927.2 → NP_001119399.1  DNA replication protein-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001119399.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3H4Z5
    Conserved Domains (1) summary
    cd11711
    Location:21 → 139
    GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5

  2. NM_124278.4 → NP_199712.2  DNA replication protein-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_199712.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q6NQP5, Q9FI69
    UniProtKB/TrEMBL
    A0A178UAX9, A0A7G2FJ75
    Conserved Domains (2) summary
    cd11711
    Location:21 → 139
    GINS_A_Sld5; Alpha-helical domain of GINS complex protein Sld5
    pfam16922
    Location:165 → 220
    SLD5_C; DNA replication complex GINS protein SLD5 C-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NQP5.1

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