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Gsdmc gasdermin C [ Mus musculus (house mouse) ]

Gene ID: 83492, updated on 8-Feb-2024

Summary

Official Symbol
Gsdmcprovided by MGI
Official Full Name
gasdermin Cprovided by MGI
Primary source
MGI:MGI:1933176
See related
Ensembl:ENSMUSG00000079025 AllianceGenome:MGI:1933176
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mlze; Gsdmc1
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to act upstream of or within programmed cell death. Predicted to be located in cytoplasm. Is expressed in gut and urinary system. Orthologous to human GSDMC (gasdermin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 17.3), colon adult (RPKM 12.5) and 3 other tissues See more
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Genomic context

See Gsdmc in Genome Data Viewer
Location:
15 D1; 15 27.79 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (63647820..63680588, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (63775971..63808739, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41336 Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2 pseudogene Neighboring gene gasdermin pseudogene Neighboring gene gasdermin C2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables wide pore channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within programmed cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyroptosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gasdermin-C
Names
gasdermin C1
melanoma-derived leucine zipper, extra-nuclear factor
melanoma-derived leucine zipper-containing extranuclear factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031378.3NP_113555.1  gasdermin-C

    See identical proteins and their annotated locations for NP_113555.1

    Status: PROVISIONAL

    Source sequence(s)
    AK137662
    Consensus CDS
    CCDS37086.1
    UniProtKB/Swiss-Prot
    Q99NB5
    UniProtKB/TrEMBL
    G3UXG6
    Related
    ENSMUSP00000105752.3, ENSMUST00000110125.9
    Conserved Domains (1) summary
    pfam04598
    Location:4442
    Gasdermin; Gasdermin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    63647820..63680588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)