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Rbm5 RNA binding motif protein 5 [ Mus musculus (house mouse) ]

Gene ID: 83486, updated on 12-May-2024

Summary

Official Symbol
Rbm5provided by MGI
Official Full Name
RNA binding motif protein 5provided by MGI
Primary source
MGI:MGI:1933204
See related
Ensembl:ENSMUSG00000032580 AllianceGenome:MGI:1933204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D030069N10Rik
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of apoptotic process; regulation of alternative mRNA splicing, via spliceosome; and spliceosomal complex assembly. Predicted to act upstream of or within RNA splicing; apoptotic process; and mRNA processing. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in central nervous system; lung; sensory organ; and testis. Orthologous to human RBM5 (RNA binding motif protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 44.1), CNS E11.5 (RPKM 42.8) and 28 other tissues See more
Orthologs
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Genomic context

See Rbm5 in Genome Data Viewer
Location:
9 F1; 9 59.07 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107617694..107648228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107740495..107771007, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F Neighboring gene STARR-seq mESC enhancer starr_25187 Neighboring gene predicted gene, 51690 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107637781-107637982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107638598-107638781 Neighboring gene predicted gene, 34605 Neighboring gene STARR-seq mESC enhancer starr_25188 Neighboring gene RNA binding motif protein 6 Neighboring gene STARR-positive B cell enhancer ABC_E6802 Neighboring gene MON1 homolog A, secretory traffciking associated

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in spliceosomal complex assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA-binding protein 5
Names
putative tumor suppressor LUCA15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359524.1NP_001346453.1  RNA-binding protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC152718
    Consensus CDS
    CCDS90660.1
    Related
    ENSMUSP00000035199.7, ENSMUST00000035199.13
    Conserved Domains (6) summary
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam00641
    Location:181210
    zf-RanBP; Zn-finger in Ran binding protein and others
    cd16168
    Location:455509
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam01585
    Location:742786
    G-patch; G-patch domain
  2. NM_001359525.1NP_001346454.1  RNA-binding protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC152718
    Consensus CDS
    CCDS23506.1
    UniProtKB/Swiss-Prot
    Q3UZ19, Q91YE7, Q99KV9
    Conserved Domains (6) summary
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:455510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:183210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743785
    G-patch; G-patch domain
  3. NM_001359526.1NP_001346455.1  RNA-binding protein 5 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC152718
    Consensus CDS
    CCDS23506.1
    UniProtKB/Swiss-Prot
    Q3UZ19, Q91YE7, Q99KV9
    Conserved Domains (6) summary
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:455510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:183210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743785
    G-patch; G-patch domain
  4. NM_148930.3NP_683732.1  RNA-binding protein 5 isoform 1

    See identical proteins and their annotated locations for NP_683732.1

    Status: VALIDATED

    Source sequence(s)
    AK146880, AW047301, BY140862
    Consensus CDS
    CCDS23506.1
    UniProtKB/Swiss-Prot
    Q3UZ19, Q91YE7, Q99KV9
    Related
    ENSMUSP00000138379.2, ENSMUST00000182659.8
    Conserved Domains (6) summary
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:455510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:183210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743785
    G-patch; G-patch domain

RNA

  1. NR_153190.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC152718
  2. NR_153191.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC152718
    Related
    ENSMUST00000182371.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107617694..107648228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511872.3XP_006511935.1  RNA-binding protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006511935.1

    UniProtKB/Swiss-Prot
    Q3UZ19, Q91YE7, Q99KV9
    Conserved Domains (6) summary
    cd12752
    Location:93179
    RRM1_RBM5; RNA recognition motif 1 in vertebrate RNA-binding protein 5 (RBM5)
    cd12755
    Location:229314
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:185204
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:455510
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:183210
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:743785
    G-patch; G-patch domain
  2. XM_006511875.3XP_006511938.1  RNA-binding protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006511938.1

    Conserved Domains (3) summary
    cd16168
    Location:208263
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam01585
    Location:496538
    G-patch; G-patch domain
    cl17169
    Location:167
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. XM_030244735.2XP_030100595.1  RNA-binding protein 5 isoform X3

    Conserved Domains (5) summary
    cd12755
    Location:57142
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:1332
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:283337
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:1138
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:570612
    G-patch; G-patch domain
  4. XM_030244732.2XP_030100592.1  RNA-binding protein 5 isoform X2

    Conserved Domains (5) summary
    cd12755
    Location:57142
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:1332
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:283338
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:1138
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:571613
    G-patch; G-patch domain
  5. XM_030244734.2XP_030100594.1  RNA-binding protein 5 isoform X2

    Conserved Domains (5) summary
    cd12755
    Location:57142
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:1332
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:283338
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:1138
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:571613
    G-patch; G-patch domain
  6. XM_030244733.2XP_030100593.1  RNA-binding protein 5 isoform X2

    Conserved Domains (5) summary
    cd12755
    Location:57142
    RRM2_RBM5; RNA recognition motif 2 in vertebrate RNA-binding protein 5 (RBM5)
    sd00025
    Location:1332
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    cd16168
    Location:283338
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam00641
    Location:1138
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam01585
    Location:571613
    G-patch; G-patch domain
  7. XM_006511876.1XP_006511939.1  RNA-binding protein 5 isoform X4

    See identical proteins and their annotated locations for XP_006511939.1

    Related
    ENSMUST00000194801.6
    Conserved Domains (3) summary
    cd16168
    Location:208263
    OCRE_RBM5; OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins
    pfam01585
    Location:496538
    G-patch; G-patch domain
    cl17169
    Location:167
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_001779079.3 RNA Sequence