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SCRT1 scratch family transcriptional repressor 1 [ Homo sapiens (human) ]

Gene ID: 83482, updated on 13-Mar-2020

Summary

Official Symbol
SCRT1provided by HGNC
Official Full Name
scratch family transcriptional repressor 1provided by HGNC
Primary source
HGNC:HGNC:15950
See related
Ensembl:ENSG00000261678 MIM:605858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SCRT; ZNF898
Summary
This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]
Expression
Biased expression in brain (RPKM 4.1), adrenal (RPKM 0.6) and 1 other tissue See more
Orthologs

Genomic context

See SCRT1 in Genome Data Viewer
Location:
8q24.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144330565..144336482, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145554228..145559943, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 1 Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene microRNA 6848 Neighboring gene transmembrane protein 249 Neighboring gene F-box and leucine rich repeat protein 6 Neighboring gene solute carrier family 52 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
NHGRI GWA Catalog

General gene information

Markers

Homology

Clone Names

  • DKFZp547F072

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of neuron migration IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
transcriptional repressor scratch 1
Names
scratch family zinc finger 1
scratch homolog 1, zinc finger protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031309.6NP_112599.2  transcriptional repressor scratch 1

    See identical proteins and their annotated locations for NP_112599.2

    Status: REVIEWED

    Source sequence(s)
    AC233992
    Consensus CDS
    CCDS6421.1
    UniProtKB/Swiss-Prot
    Q9BWW7
    Related
    ENSP00000455711.1, ENST00000569446.3
    Conserved Domains (2) summary
    COG5048
    Location:245313
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:250270
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144330565..144336482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447291.1XP_024303059.1  transcriptional repressor scratch 1 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:178246
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:183203
    ZF_C2H2; C2H2 Zn finger [structural motif]

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654716.1 Reference GRCh38.p13 PATCHES

    Range
    61168..67085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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