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DDX59 DEAD-box helicase 59 [ Homo sapiens (human) ]

Gene ID: 83479, updated on 25-Apr-2020

Summary

Official Symbol
DDX59provided by HGNC
Official Full Name
DEAD-box helicase 59provided by HGNC
Primary source
HGNC:HGNC:25360
See related
Ensembl:ENSG00000118197 MIM:615464
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OFD5; ZNHIT5
Expression
Ubiquitous expression in bone marrow (RPKM 2.6), thyroid (RPKM 2.3) and 25 other tissues See more
Orthologs

Genomic context

See DDX59 in Genome Data Viewer
Location:
1q32.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (200640805..200669998, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200609935..200639126, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985459 Neighboring gene kinesin family member 14 Neighboring gene DDX59 antisense RNA 1 Neighboring gene calmodulin regulated spectrin associated protein family member 2 Neighboring gene ribosomal protein L34 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564B1023

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX59
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
DEAD box protein 59
zinc finger HIT domain-containing protein 5
NP_001026895.2
NP_001307110.1
NP_001307111.1
NP_001336728.1
NP_001336729.1
NP_001336730.1
NP_001336731.1
NP_001336732.1
NP_001336733.1
XP_016857921.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053192.1 RefSeqGene

    Range
    5001..30962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001031725.6NP_001026895.2  probable ATP-dependent RNA helicase DDX59 isoform 1

    See identical proteins and their annotated locations for NP_001026895.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 4 and 5 all encode the same isoform (1).
    Source sequence(s)
    AL445483
    Consensus CDS
    CCDS30964.1
    UniProtKB/Swiss-Prot
    Q5T1V6
    Related
    ENSP00000330460.6, ENST00000331314.11
    Conserved Domains (1) summary
    cl26939
    Location:89592
    DEXDc; DEAD-like helicases superfamily
  2. NM_001320181.2NP_001307110.1  probable ATP-dependent RNA helicase DDX59 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL445483
    UniProtKB/Swiss-Prot
    Q5T1V6
    UniProtKB/TrEMBL
    B7Z5N6
    Conserved Domains (4) summary
    smart00487
    Location:218413
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:416531
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:205405
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam04438
    Location:105132
    zf-HIT; HIT zinc finger
  3. NM_001320182.1NP_001307111.1  probable ATP-dependent RNA helicase DDX59 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. The first exon (5' UTR) of this variant has not been determined.
    Source sequence(s)
    AL445483, BC041801, BU621052, BU754283
    UniProtKB/Swiss-Prot
    Q5T1V6
    Conserved Domains (4) summary
    PLN00206
    Location:89478
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional
    cd00079
    Location:319434
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam04438
    Location:105132
    zf-HIT; HIT zinc finger
    cl21455
    Location:205321
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  4. NM_001349799.2NP_001336728.1  probable ATP-dependent RNA helicase DDX59 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1 and 5, encodes isoform 1.
    Source sequence(s)
    AK299219, AL445483
    Consensus CDS
    CCDS30964.1
    Conserved Domains (1) summary
    cl26939
    Location:89592
    DEXDc; DEAD-like helicases superfamily
  5. NM_001349800.2NP_001336729.1  probable ATP-dependent RNA helicase DDX59 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1 and 4, encodes isoform 1.
    Source sequence(s)
    AK299219, AL445483
    Consensus CDS
    CCDS30964.1
    Conserved Domains (1) summary
    cl26939
    Location:89592
    DEXDc; DEAD-like helicases superfamily
  6. NM_001349801.2NP_001336730.1  probable ATP-dependent RNA helicase DDX59 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) encodes isoform 4.
    Source sequence(s)
    AK299219, AL445483
    Conserved Domains (1) summary
    cl26939
    Location:89549
    DEXDc; DEAD-like helicases superfamily
  7. NM_001349802.3NP_001336731.1  probable ATP-dependent RNA helicase DDX59 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) encodes isoform 5.
    Source sequence(s)
    AL445483
    Related
    ENSP00000394367.2, ENST00000447706.6
    Conserved Domains (1) summary
    cl26939
    Location:89532
    DEXDc; DEAD-like helicases superfamily
  8. NM_001349803.2NP_001336732.1  probable ATP-dependent RNA helicase DDX59 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform 6.
    Source sequence(s)
    AK299219, AL445483
    Conserved Domains (1) summary
    cl26939
    Location:89508
    DEXDc; DEAD-like helicases superfamily
  9. NM_001349804.1NP_001336733.1  probable ATP-dependent RNA helicase DDX59 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) encodes isoform 7.
    Source sequence(s)
    AL445483
    Conserved Domains (1) summary
    cl26939
    Location:89355
    DEXDc; DEAD-like helicases superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    200640805..200669998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002432.2XP_016857921.1  probable ATP-dependent RNA helicase DDX59 isoform X1

    UniProtKB/Swiss-Prot
    Q5T1V6
    Conserved Domains (1) summary
    cl26939
    Location:89592
    DEXDc; DEAD-like helicases superfamily

RNA

  1. XR_001737463.2 RNA Sequence

  2. XR_921967.3 RNA Sequence

  3. XR_921966.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_031306.2: Suppressed sequence

    Description
    NM_031306.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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