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DOHH deoxyhypusine hydroxylase [ Homo sapiens (human) ]

Gene ID: 83475, updated on 8-Jul-2021

Summary

Official Symbol
DOHHprovided by HGNC
Official Full Name
deoxyhypusine hydroxylaseprovided by HGNC
Primary source
HGNC:HGNC:28662
See related
Ensembl:ENSG00000129932 MIM:611262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLRC1; hDOHH
Summary
This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Expression
Ubiquitous expression in kidney (RPKM 3.6), brain (RPKM 3.1) and 25 other tissues See more
Orthologs
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Genomic context

See DOHH in Genome Data Viewer
Location:
19p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (3490824..3500674, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (3490822..3500672, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 24 Neighboring gene uncharacterized LOC105372246 Neighboring gene uncharacterized LOC105372245 Neighboring gene fizzy and cell division cycle 20 related 1 Neighboring gene chromosome 19 open reading frame 71 Neighboring gene major facilitator superfamily domain containing 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with deoxyhypusine hydroxylase/monooxygenase (DOHH) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC4293

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables deoxyhypusine monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxyhypusine monooxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables iron ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in peptidyl-lysine modification to peptidyl-hypusine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-lysine modification to peptidyl-hypusine IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
deoxyhypusine hydroxylase
Names
HEAT-like (PBS lyase) repeat containing 1
HEAT-like repeat-containing protein 1
deoxyhypusine dioxygenase
deoxyhypusine hydroxylase/monooxygenase
deoxyhypusine monooxygenase
NP_001138637.1
NP_112594.1
XP_011526643.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145165.2NP_001138637.1  deoxyhypusine hydroxylase

    See identical proteins and their annotated locations for NP_001138637.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC002817, BG491509, BU624567
    Consensus CDS
    CCDS12108.1
    UniProtKB/Swiss-Prot
    Q9BU89
    Related
    ENSP00000398882.1, ENST00000427575.6
    Conserved Domains (2) summary
    COG1413
    Location:45298
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:69100
    HEAT; HEAT repeat [structural motif]
  2. NM_031304.5NP_112594.1  deoxyhypusine hydroxylase

    See identical proteins and their annotated locations for NP_112594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC005787, BC002817, BU624567
    Consensus CDS
    CCDS12108.1
    UniProtKB/Swiss-Prot
    Q9BU89
    Related
    ENSP00000500806.1, ENST00000672935.1
    Conserved Domains (2) summary
    COG1413
    Location:45298
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:69100
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    3490824..3500674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528341.2XP_011526643.1  deoxyhypusine hydroxylase isoform X1

    Conserved Domains (3) summary
    smart00567
    Location:85114
    EZ_HEAT; E-Z type HEAT repeats
    pfam13646
    Location:41114
    HEAT_2; HEAT repeats
    sd00044
    Location:69100
    HEAT; HEAT repeat [structural motif]
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