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KATNAL2 katanin catalytic subunit A1 like 2 [ Homo sapiens (human) ]

Gene ID: 83473, updated on 4-Nov-2022

Summary

Official Symbol
KATNAL2provided by HGNC
Official Full Name
katanin catalytic subunit A1 like 2provided by HGNC
Primary source
HGNC:HGNC:25387
See related
Ensembl:ENSG00000167216 MIM:614697; AllianceGenome:HGNC:25387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 2.3), thyroid (RPKM 1.9) and 23 other tissues See more
Orthologs
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Genomic context

See KATNAL2 in Genome Data Viewer
Location:
18q21.1
Exon count:
21
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (46917594..47102243)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (47108258..47292540)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (44497557..44628614)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene protein inhibitor of activated STAT 2 Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) pseudogene Neighboring gene uncharacterized LOC124904294 Neighboring gene elongin A3 family member D, pseudogene Neighboring gene elongin A3 family member B, pseudogene Neighboring gene elongin A2 Neighboring gene uncharacterized LOC105372098 Neighboring gene small ubiquitin-related modifier 2-like Neighboring gene haloacid dehalogenase like hydrolase domain containing 2 Neighboring gene immediate early response 3 interacting protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2018-11-28)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2018-11-28)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Meta-analysis of genome-wide association studies for personality.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33211, DKFZp667C165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule severing ATPase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cytoplasmic microtubule organization IC
Inferred by Curator
more info
PubMed 
involved_in microtubule severing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of katanin complex IC
Inferred by Curator
more info
 
located_in microtubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton IC
Inferred by Curator
more info
PubMed 
located_in spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
katanin p60 ATPase-containing subunit A-like 2
Names
katanin catalytic subunit A like 2
katanin p60 subunit A like 2
p60 katanin-like 2
NP_001340828.1
NP_001340829.1
NP_001340830.1
NP_001340831.1
NP_001340832.1
NP_001340833.1
NP_001340834.1
NP_001340835.1
NP_001340836.1
NP_001340837.1
NP_001340838.1
NP_001354550.1
NP_001374619.1
NP_112593.2
XP_005258418.1
XP_011524521.1
XP_011524522.1
XP_011524523.1
XP_011524525.1
XP_016881520.1
XP_047293833.1
XP_047293834.1
XP_047293835.1
XP_047293836.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001353899.1NP_001340828.1  katanin p60 ATPase-containing subunit A-like 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373, CA311572
    Conserved Domains (2) summary
    smart00667
    Location:5181
    LisH; Lissencephaly type-1-like homology motif
    COG0464
    Location:264559
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  2. NM_001353900.1NP_001340829.1  katanin p60 ATPase-containing subunit A-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373, CA311572
    Conserved Domains (2) summary
    smart00667
    Location:5181
    LisH; Lissencephaly type-1-like homology motif
    COG0464
    Location:263558
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  3. NM_001353901.1NP_001340830.1  katanin p60 ATPase-containing subunit A-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Conserved Domains (2) summary
    smart00667
    Location:2555
    LisH; Lissencephaly type-1-like homology motif
    COG0464
    Location:238426
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  4. NM_001353902.1NP_001340831.1  katanin p60 ATPase-containing subunit A-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Related
    ENSP00000510745.1, ENST00000686215.1
    Conserved Domains (2) summary
    smart00667
    Location:5181
    LisH; Lissencephaly type-1-like homology motif
    COG0464
    Location:152419
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  5. NM_001353903.1NP_001340832.1  katanin p60 ATPase-containing subunit A-like 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373, CA311572
    Consensus CDS
    CCDS92457.1
    UniProtKB/TrEMBL
    K7EIJ8
    Conserved Domains (1) summary
    COG0464
    Location:127422
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  6. NM_001353904.1NP_001340833.1  katanin p60 ATPase-containing subunit A-like 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373, CA311572
    Conserved Domains (1) summary
    COG0464
    Location:15389
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  7. NM_001353905.1NP_001340834.1  katanin p60 ATPase-containing subunit A-like 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Conserved Domains (1) summary
    COG0464
    Location:127315
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  8. NM_001353906.1NP_001340835.1  katanin p60 ATPase-containing subunit A-like 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Conserved Domains (1) summary
    COG0464
    Location:127315
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  9. NM_001353907.1NP_001340836.1  katanin p60 ATPase-containing subunit A-like 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Related
    ENSP00000509033.1, ENST00000687291.1
    Conserved Domains (1) summary
    COG0464
    Location:127293
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  10. NM_001353908.1NP_001340837.1  katanin p60 ATPase-containing subunit A-like 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Consensus CDS
    CCDS92458.1
    UniProtKB/TrEMBL
    K7EPQ6
    Related
    ENSP00000467488.2, ENST00000591522.2
    Conserved Domains (1) summary
    COG0464
    Location:15282
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  11. NM_001353909.1NP_001340838.1  katanin p60 ATPase-containing subunit A-like 2 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Conserved Domains (1) summary
    COG0464
    Location:15259
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  12. NM_001367621.1NP_001354550.1  katanin p60 ATPase-containing subunit A-like 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Consensus CDS
    CCDS92456.1
    UniProtKB/Swiss-Prot
    Q8IYT4
    Related
    ENSP00000348478.6, ENST00000356157.12
    Conserved Domains (3) summary
    smart00667
    Location:2555
    LisH; Lissencephaly type-1-like homology motif
    pfam17862
    Location:450494
    AAA_lid_3; AAA+ lid domain
    cd19509
    Location:256420
    RecA-like_VPS4-like; ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains
  13. NM_001387690.1NP_001374619.1  katanin p60 ATPase-containing subunit A-like 2 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373
    Consensus CDS
    CCDS92456.1
    UniProtKB/Swiss-Prot
    Q8IYT4
    Related
    ENSP00000508137.1, ENST00000683218.1
    Conserved Domains (3) summary
    smart00667
    Location:2555
    LisH; Lissencephaly type-1-like homology motif
    pfam17862
    Location:450494
    AAA_lid_3; AAA+ lid domain
    cd19509
    Location:256420
    RecA-like_VPS4-like; ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains
  14. NM_031303.3NP_112593.2  katanin p60 ATPase-containing subunit A-like 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC012254, BC034999, BI561067, CA311572, CN303333
    Consensus CDS
    CCDS32828.1
    UniProtKB/Swiss-Prot
    Q8IYT4
    Related
    ENSP00000245121.4, ENST00000245121.10
    Conserved Domains (2) summary
    cd19509
    Location:184348
    RecA-like_VPS4-like; ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains
    pfam17862
    Location:378422
    AAA_lid_3; AAA+ lid domain

RNA

  1. NR_148563.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC012254, AC090373, CA311572

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    46917594..47102243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437879.1XP_047293835.1  katanin p60 ATPase-containing subunit A-like 2 isoform X5

  2. XM_011526220.3XP_011524522.1  katanin p60 ATPase-containing subunit A-like 2 isoform X3

    Conserved Domains (3) summary
    smart00667
    Location:5181
    LisH; Lissencephaly type-1-like homology motif
    smart00382
    Location:312448
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:316429
    AAA; ATPase family associated with various cellular activities (AAA)
  3. XM_047437880.1XP_047293836.1  katanin p60 ATPase-containing subunit A-like 2 isoform X6

  4. XM_047437878.1XP_047293834.1  katanin p60 ATPase-containing subunit A-like 2 isoform X4

  5. XM_011526221.4XP_011524523.1  katanin p60 ATPase-containing subunit A-like 2 isoform X7

    Conserved Domains (3) summary
    smart00667
    Location:5181
    LisH; Lissencephaly type-1-like homology motif
    smart00382
    Location:312441
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:316431
    AAA; ATPase family associated with various cellular activities (AAA)
  6. XM_011526223.4XP_011524525.1  katanin p60 ATPase-containing subunit A-like 2 isoform X8

    Conserved Domains (3) summary
    smart00667
    Location:5181
    LisH; Lissencephaly type-1-like homology motif
    COG0464
    Location:264429
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:316429
    AAA; ATPase family associated with various cellular activities (AAA)
  7. XM_011526219.4XP_011524521.1  katanin p60 ATPase-containing subunit A-like 2 isoform X1

    Conserved Domains (3) summary
    smart00667
    Location:5181
    LisH; Lissencephaly type-1-like homology motif
    COG0464
    Location:264429
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
    pfam00004
    Location:316429
    AAA; ATPase family associated with various cellular activities (AAA)
  8. XM_047437877.1XP_047293833.1  katanin p60 ATPase-containing subunit A-like 2 isoform X2

  9. XM_017026031.2XP_016881520.1  katanin p60 ATPase-containing subunit A-like 2 isoform X9

    UniProtKB/TrEMBL
    K7EIJ8
    Conserved Domains (1) summary
    COG0464
    Location:127422
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
  10. XM_005258361.4XP_005258418.1  katanin p60 ATPase-containing subunit A-like 2 isoform X9

    UniProtKB/TrEMBL
    K7EIJ8
    Related
    ENSP00000464779.2, ENST00000588433.6
    Conserved Domains (1) summary
    COG0464
    Location:127422
    SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    47108258..47292540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)