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CDCA3 cell division cycle associated 3 [ Homo sapiens (human) ]

Gene ID: 83461, updated on 9-Feb-2020

Summary

Official Symbol
CDCA3provided by HGNC
Official Full Name
cell division cycle associated 3provided by HGNC
Primary source
HGNC:HGNC:14624
See related
Ensembl:ENSG00000111665 MIM:607749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GRCC8; TOME-1
Expression
Broad expression in testis (RPKM 6.4), duodenum (RPKM 3.8) and 20 other tissues See more
Orthologs

Genomic context

See CDCA3 in Genome Data Viewer
Location:
12p13.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6844795..6852079, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6957972..6961128, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 162 Neighboring gene prolyl 3-hydroxylase 3 Neighboring gene G protein subunit beta 3 Neighboring gene ubiquitin specific peptidase 5 Neighboring gene triosephosphate isomerase 1 Neighboring gene splA/ryanodine receptor domain and SOCS box containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cell division cycle-associated protein 3
Names
gene-rich cluster protein C8
trigger of mitotic entry protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297602.2NP_001284531.1  cell division cycle-associated protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    U47924
    Consensus CDS
    CCDS76512.1
    UniProtKB/TrEMBL
    J3KMY0
    Related
    ENSP00000229265.5, ENST00000229265.10
    Conserved Domains (1) summary
    PHA03247
    Location:2156
    PHA03247; large tegument protein UL36; Provisional
  2. NM_001297603.2NP_001284532.1  cell division cycle-associated protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001284532.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' structure, resulting in a novel 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a distinct C-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AK092246, AK291421, U47924
    Consensus CDS
    CCDS76513.1
    UniProtKB/Swiss-Prot
    Q99618
    UniProtKB/TrEMBL
    F8WDL1
    Related
    ENSP00000415142.2, ENST00000422785.7
  3. NM_001297604.2NP_001284533.1  cell division cycle-associated protein 3 isoform 4

    See identical proteins and their annotated locations for NP_001284533.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (4) has a distinct C-terminus, and is shorter, compared to isoform 1.
    Source sequence(s)
    AK291421, BQ961607, U47924
    Consensus CDS
    CCDS73428.1
    UniProtKB/Swiss-Prot
    Q99618
    UniProtKB/TrEMBL
    F5GX58
    Related
    ENSP00000441120.1, ENST00000540683.1
  4. NM_001331019.1NP_001317948.1  cell division cycle-associated protein 3 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the both the 5' and 3' coding regions and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (5) has a shorter N-terminus and distict, shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AK291421, AV714087, U47924
    UniProtKB/Swiss-Prot
    Q99618
  5. NM_031299.6NP_112589.1  cell division cycle-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_112589.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK291421, U47924
    Consensus CDS
    CCDS8565.1
    UniProtKB/Swiss-Prot
    Q99618
    Related
    ENSP00000442068.1, ENST00000538862.6

RNA

  1. NR_123727.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK291421, DA735127, U47924
  2. NR_138531.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an exon in the 5' region and uses an alternate splice site in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 6, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    U47924

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6844795..6852079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002957383.1 RNA Sequence

  2. XR_001748881.2 RNA Sequence

  3. XR_001748880.2 RNA Sequence

  4. XR_002957385.1 RNA Sequence

  5. XR_001748879.2 RNA Sequence

  6. XR_002957384.1 RNA Sequence

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