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GSG1 germ cell associated 1 [ Homo sapiens (human) ]

Gene ID: 83445, updated on 11-Jun-2021

Summary

Official Symbol
GSG1provided by HGNC
Official Full Name
germ cell associated 1provided by HGNC
Primary source
HGNC:HGNC:19716
See related
Ensembl:ENSG00000111305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Restricted expression toward testis (RPKM 69.4) See more
Orthologs
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Genomic context

See GSG1 in Genome Data Viewer
Location:
12p13.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (13083532..13103678, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13236466..13256601, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene ribosomal protein S26 pseudogene 46 Neighboring gene family with sequence similarity 234 member B Neighboring gene uncharacterized LOC105369666 Neighboring gene Sharpr-MPRA regulatory region 6201 Neighboring gene epithelial membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3146, MGC111023

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
germ cell-specific gene 1 protein
Names
testicular secretory protein Li 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080554.4NP_001074023.1  germ cell-specific gene 1 protein isoform 3

    See identical proteins and their annotated locations for NP_001074023.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and includes an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC023790, AC079628
    Consensus CDS
    CCDS44836.1
    UniProtKB/Swiss-Prot
    Q2KHT4
    UniProtKB/TrEMBL
    F1T0A1, G3XAB9
    Related
    ENSP00000336857.6, ENST00000351606.10
    Conserved Domains (1) summary
    pfam07803
    Location:24160
    GSG-1; GSG1-like protein
  2. NM_001080555.4NP_001074024.1  germ cell-specific gene 1 protein isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region, includes an alternate in-frame exon in the central coding region, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AC023790, AC079628
    UniProtKB/TrEMBL
    F1T0A1
    Related
    ENSP00000498528.1, ENST00000651961.1
    Conserved Domains (1) summary
    pfam07803
    Location:24160
    GSG-1; GSG1-like protein
  3. NM_001206842.3NP_001193771.1  germ cell-specific gene 1 protein isoform 5

    See identical proteins and their annotated locations for NP_001193771.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region, and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (5) has distinct N- and C-termini and is longer than isoform 1.
    Source sequence(s)
    AC023790, AC079628
    Consensus CDS
    CCDS55808.1
    UniProtKB/Swiss-Prot
    Q2KHT4
    UniProtKB/TrEMBL
    F1T0A1
    Related
    ENSP00000405032.2, ENST00000432710.6
    Conserved Domains (1) summary
    pfam07803
    Location:24137
    GSG-1; GSG1-like protein
  4. NM_001206843.3NP_001193772.1  germ cell-specific gene 1 protein isoform 6

    See identical proteins and their annotated locations for NP_001193772.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) includes an alternate in-frame exon in the central coding region and uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (6) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC023790
    Consensus CDS
    CCDS55807.1
    UniProtKB/Swiss-Prot
    Q2KHT4
    UniProtKB/TrEMBL
    F1T0A1
    Related
    ENSP00000441718.1, ENST00000537302.5
    Conserved Domains (1) summary
    pfam07803
    Location:11147
    GSG-1; GSG1-like protein
  5. NM_001206845.3NP_001193774.1  germ cell-specific gene 1 protein isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site and lacks an alternate exon, resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (7) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC023790
    Consensus CDS
    CCDS55806.1
    UniProtKB/Swiss-Prot
    Q2KHT4
    UniProtKB/TrEMBL
    F1T0A1
    Related
    ENSP00000398384.2, ENST00000457134.6
    Conserved Domains (1) summary
    pfam07803
    Location:11124
    GSG-1; GSG1-like protein
  6. NM_001367358.2NP_001354287.1  germ cell-specific gene 1 protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC023790, AC079628
    Conserved Domains (1) summary
    pfam07803
    Location:24160
    GSG-1; GSG1-like protein
  7. NM_001367359.2NP_001354288.1  germ cell-specific gene 1 protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC023790, AC079628
    Conserved Domains (1) summary
    pfam07803
    Location:24184
    GSG-1; GSG1-like protein
  8. NM_001367360.2NP_001354289.1  germ cell-specific gene 1 protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC023790, AC079628
    Conserved Domains (1) summary
    pfam07803
    Location:24160
    GSG-1; GSG1-like protein
  9. NM_001367361.2NP_001354290.1  germ cell-specific gene 1 protein isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC023790, AC079628
    Conserved Domains (1) summary
    pfam07803
    Location:24184
    GSG-1; GSG1-like protein
  10. NM_001367362.2NP_001354291.1  germ cell-specific gene 1 protein isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC023790, AC079628
    Conserved Domains (1) summary
    pfam07803
    Location:24160
    GSG-1; GSG1-like protein
  11. NM_001367363.2NP_001354292.1  germ cell-specific gene 1 protein isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC023790, AC079628
    Conserved Domains (1) summary
    pfam07803
    Location:24160
    GSG-1; GSG1-like protein
  12. NM_001367364.2NP_001354293.1  germ cell-specific gene 1 protein isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC023790, AC079628
    Conserved Domains (1) summary
    pfam07803
    Location:24137
    GSG-1; GSG1-like protein
  13. NM_001367366.1NP_001354295.1  germ cell-specific gene 1 protein isoform 15

    Status: VALIDATED

    Source sequence(s)
    AA776786, AC079628
  14. NM_001368007.2NP_001354936.1  germ cell-specific gene 1 protein isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC023790
  15. NM_031289.5NP_112579.2  germ cell-specific gene 1 protein isoform 1

    See identical proteins and their annotated locations for NP_112579.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC023790
    Consensus CDS
    CCDS8659.2
    UniProtKB/Swiss-Prot
    Q2KHT4
    UniProtKB/TrEMBL
    F1T0A0, F1T0A1
    Related
    ENSP00000379596.3, ENST00000396302.7
    Conserved Domains (1) summary
    pfam07803
    Location:11124
    GSG-1; GSG1-like protein
  16. NM_153823.5NP_722545.2  germ cell-specific gene 1 protein isoform 2

    See identical proteins and their annotated locations for NP_722545.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is longer than isoform 1.
    Source sequence(s)
    AC023790
    Consensus CDS
    CCDS44835.1
    UniProtKB/TrEMBL
    F1T0A1
    Related
    ENSP00000336816.6, ENST00000337630.10
    Conserved Domains (1) summary
    pfam07803
    Location:11124
    GSG-1; GSG1-like protein

RNA

  1. NR_159953.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC079628

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    13083532..13103678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520858.1XP_011519160.1  germ cell-specific gene 1 protein isoform X1

    Conserved Domains (1) summary
    pfam07803
    Location:24184
    GSG-1; GSG1-like protein
  2. XM_011520860.1XP_011519162.1  germ cell-specific gene 1 protein isoform X4

    Conserved Domains (1) summary
    pfam07803
    Location:24184
    GSG-1; GSG1-like protein
  3. XM_011520862.1XP_011519164.1  germ cell-specific gene 1 protein isoform X7

    Conserved Domains (1) summary
    pfam07803
    Location:24160
    GSG-1; GSG1-like protein
  4. XM_011520861.2XP_011519163.1  germ cell-specific gene 1 protein isoform X5

    Conserved Domains (1) summary
    pfam07803
    Location:24137
    GSG-1; GSG1-like protein
  5. XM_011520863.2XP_011519165.1  germ cell-specific gene 1 protein isoform X8

    Conserved Domains (1) summary
    pfam07803
    Location:24137
    GSG-1; GSG1-like protein
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