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SF3B5 splicing factor 3b subunit 5 [ Homo sapiens (human) ]

Gene ID: 83443, updated on 27-Nov-2024

Summary

Official Symbol
SF3B5provided by HGNC
Official Full Name
splicing factor 3b subunit 5provided by HGNC
Primary source
HGNC:HGNC:21083
See related
Ensembl:ENSG00000169976 MIM:617847; AllianceGenome:HGNC:21083
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Ysf3; SF3b10
Summary
Enables RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U12-type spliceosomal complex and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See SF3B5 in Genome Data Viewer
Location:
6q24.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (144094884..144095573, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (145287613..145288302, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (144416021..144416710, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene PLAG1 like zinc finger 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:144328825-144329007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17633 Neighboring gene hydatidiform mole associated and imprinted Neighboring gene FKBP prolyl isomerase 7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17637 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:144410739-144410950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25211 Neighboring gene uncharacterized LOC105378036 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 3

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC3133

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables splicing factor binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SAGA complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2 snRNP NAS
Non-traceable Author Statement
more info
PubMed 
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2-type spliceosomal complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of spliceosomal complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
splicing factor 3B subunit 5
Names
pre-mRNA-splicing factor SF3b 10 kDa subunit
splicing factor 3b, subunit 5, 10kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031287.3NP_112577.1  splicing factor 3B subunit 5

    See identical proteins and their annotated locations for NP_112577.1

    Status: VALIDATED

    Source sequence(s)
    AK074417
    Consensus CDS
    CCDS5204.1
    UniProtKB/Swiss-Prot
    B2R568, Q7RTV1, Q9BWJ5
    Related
    ENSP00000356541.2, ENST00000367569.4
    Conserved Domains (1) summary
    pfam07189
    Location:377
    SF3b10; Splicing factor 3B subunit 10 (SF3b10)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    144094884..144095573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    145287613..145288302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)