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ADPGK ADP dependent glucokinase [ Homo sapiens (human) ]

Gene ID: 83440, updated on 19-Jun-2019

Summary

Official Symbol
ADPGKprovided by HGNC
Official Full Name
ADP dependent glucokinaseprovided by HGNC
Primary source
HGNC:HGNC:25250
See related
Ensembl:ENSG00000159322 MIM:611861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADP-GK; 2610017G09Rik
Summary
ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 23.6), appendix (RPKM 19.7) and 25 other tissues See more
Orthologs

Genomic context

See ADPGK in Genome Data Viewer
Location:
15q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (72751294..72783776, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73043708..73076126, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene golgin A6 family member B Neighboring gene RNA, 7SL, cytoplasmic 853, pseudogene Neighboring gene HIG1 hypoxia inducible domain family member 2B Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene ADPGK antisense RNA 1 Neighboring gene uncharacterized LOC107984801 Neighboring gene nucleophosmin 1 pseudogene 42

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog

Pathways from BioSystems

  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Glucose metabolism, organism-specific biosystem (from REACTOME)
    Glucose metabolism, organism-specific biosystemGlucose is the major form in which dietary sugars are made available to cells of the human body. Its breakdown is a major source of energy for all cells, and is essential for the brain and red blood ...
  • Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystem (from KEGG)
    Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
  • Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystem (from KEGG)
    Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
  • Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434B195

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-specific glucokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
canonical glycolysis TAS
Traceable Author Statement
more info
 
glucose metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
ADP-dependent glucokinase
Names
ATP-dependent glucokinase
rbBP-35
NP_001352152.1
NP_001352153.1
NP_001352154.1
NP_001352155.1
NP_001352156.1
NP_001352157.1
NP_001352158.1
NP_112574.3
XP_011520406.1
XP_016878153.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365223.1NP_001352152.1  ADP-dependent glucokinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009712, AK075560, BC044589, DA031990, DA208247
    Conserved Domains (1) summary
    cd01938
    Location:1369
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
  2. NM_001365224.1NP_001352153.1  ADP-dependent glucokinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009712, AK055526, AK075560
    Conserved Domains (1) summary
    cl00192
    Location:1253
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  3. NM_001365225.1NP_001352154.1  ADP-dependent glucokinase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC009712, BC006112, DA031990
    Conserved Domains (1) summary
    cd01938
    Location:60492
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
  4. NM_001365226.1NP_001352155.1  ADP-dependent glucokinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC009712
    Conserved Domains (1) summary
    cd01938
    Location:1370
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...
  5. NM_001365227.1NP_001352156.1  ADP-dependent glucokinase isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC009712, BI906568
    Conserved Domains (1) summary
    cl00192
    Location:60353
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  6. NM_001365228.1NP_001352157.1  ADP-dependent glucokinase isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC009712, DA600729
    Conserved Domains (1) summary
    cl00192
    Location:60352
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  7. NM_001365229.1NP_001352158.1  ADP-dependent glucokinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009712
    Conserved Domains (1) summary
    cl00192
    Location:1253
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
  8. NM_031284.5NP_112574.3  ADP-dependent glucokinase isoform 1 precursor

    See identical proteins and their annotated locations for NP_112574.3

    Status: VALIDATED

    Source sequence(s)
    AC009712, AK075560, DA031990, DB279245
    Consensus CDS
    CCDS42057.1
    UniProtKB/Swiss-Prot
    Q9BRR6
    Related
    ENSP00000312250.8, ENST00000311669.12
    Conserved Domains (1) summary
    cd01938
    Location:60491
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    72751294..72783776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022664.2XP_016878153.1  ADP-dependent glucokinase isoform X6

  2. XM_011522104.3XP_011520406.1  ADP-dependent glucokinase isoform X5

    Conserved Domains (1) summary
    cl00192
    Location:60313
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...
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