Il23a interleukin 23, alpha subunit p19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il23aprovided by MGI
Official Full Name: interleukin 23, alpha subunit p19provided by MGI
Primary source: MGI:MGI:1932410
See related: Ensembl:ENSMUSG00000025383 AllianceGenome:MGI:1932410
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p19; IL-23
Summary: Contributes to interleukin-23 receptor binding activity. Involved in positive regulation of defense response to virus by host; positive regulation of immune response; and positive regulation of neutrophil chemotaxis. Acts upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Located in extracellular space. Part of interleukin-23 complex. Is expressed in decidua; decidua basalis; embryo; and extraembryonic component. Orthologous to human IL23A (interleukin 23 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 10; 10 D3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128132009..128133953, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128296140..128298084, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells.
Title: Local IL-23 is required for proliferation and retention of skin-resident memory T(H)17 cells.
Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling.
Title: Chronic stress induces colonic tertiary lymphoid organ formation and protection against secondary injury through IL-23/IL-22 signaling.
Interleukin-23 Mediates Osteoclastogenesis in Collagen-Induced Arthritis by Modulating MicroRNA-223.
Title: Interleukin-23 Mediates Osteoclastogenesis in Collagen-Induced Arthritis by Modulating MicroRNA-223.
Central role of B cells in interleukin-23 dependent neuroinflammation in the GF-IL23 model.
Title: Central role of B cells in interleukin-23 dependent neuroinflammation in the GF-IL23 model.
The role of interleukin (IL)-23 in regulating pain in arthritis.
Title: The role of interleukin (IL)-23 in regulating pain in arthritis.
Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23.
Title: Food colorants metabolized by commensal bacteria promote colitis in mice with dysregulated expression of interleukin-23.
IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.
Title: IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.
Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells.
Title: Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells.
Promotion Effect of EGCG on the Raised Expression of IL-23 through the Signaling of STAT3-BATF2-c-JUN/ATF2.
Title: Promotion Effect of EGCG on the Raised Expression of IL-23 through the Signaling of STAT3-BATF2-c-JUN/ATF2.
IL-23 in arthritic and inflammatory pain development in mice.
Title: IL-23 in arthritic and inflammatory pain development in mice.

Submit: New GeneRIF Correction See all GeneRIFs (199)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (5)

General gene information

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Markers

PMC182190P1 (e-PCR)
- UniSTS:271677

Il23a (e-PCR), detects polymorphism
- UniSTS:532618

Homology

Homologs of the Il23a gene: The Il23a gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, and rat.
Orthologs from Annotation Pipeline: 280 organisms have orthologs with human gene Il23a
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
contributes_to interleukin-23 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to interleukin-23 receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NK T cell proliferation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 1 type immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 1 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 cell lineage commitment	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of T-helper 17 cell lineage commitment	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 17 type immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T-helper 17 type immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of activation of Janus kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of activation of Janus kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of memory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tissue remodeling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-23 complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of interleukin-23 complex	IDA Inferred from Direct Assay more info	PubMed
part_of interleukin-23 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of interleukin-23 complex	ISO Inferred from Sequence Orthology more info
part_of interleukin-23 receptor complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: interleukin-23 subunit alpha

Names: IL-23 subunit alpha; IL-23-A; IL-23p19; interleukin-23 subunit p19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.