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Il23a interleukin 23, alpha subunit p19 [ Mus musculus (house mouse) ]

Gene ID: 83430, updated on 30-Nov-2021

Summary

Official Symbol
Il23aprovided by MGI
Official Full Name
interleukin 23, alpha subunit p19provided by MGI
Primary source
MGI:MGI:1932410
See related
Ensembl:ENSMUSG00000025383
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p19; IL-23
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Il23a in Genome Data Viewer
Location:
10; 10 D3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128132009..128133953, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128296140..128298084, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (127733196..127735140, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene apolipoprotein N Neighboring gene apolipoprotein F Neighboring gene signal transducer and activator of transcription 2 Neighboring gene predicted gene, 23241 Neighboring gene PAN2 poly(A) specific ribonuclease subunit Neighboring gene canopy FGF signaling regulator 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to interleukin-23 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to interleukin-23 receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NK T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NK T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 1 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 1 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 17 cell lineage commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T-helper 17 cell lineage commitment IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 17 type immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 17 type immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activation of Janus kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of granulocyte macrophage colony-stimulating factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-17 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of memory T cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of natural killer cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tissue remodeling IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-23 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of interleukin-23 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of interleukin-23 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of interleukin-23 complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-23 subunit alpha
Names
IL-23 subunit alpha
IL-23-A
IL-23p19
interleukin-23 subunit p19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031252.2NP_112542.1  interleukin-23 subunit alpha precursor

    See identical proteins and their annotated locations for NP_112542.1

    Status: VALIDATED

    Source sequence(s)
    AC135859
    Consensus CDS
    CCDS24270.1
    UniProtKB/Swiss-Prot
    Q9EQ14
    Related
    ENSMUSP00000026449.2, ENSMUST00000026449.3
    Conserved Domains (1) summary
    pfam16649
    Location:28185
    IL23; Interleukin 23 subunit alpha

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    128132009..128133953 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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