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Rack1 receptor for activated C kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 83427, updated on 8-Feb-2025

Summary

Official Symbol
Rack1provided by RGD
Official Full Name
receptor for activated C kinase 1provided by RGD
Primary source
RGD:69229
See related
EnsemblRapid:ENSRNOG00000052620 AllianceGenome:RGD:69229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gnb2l1
Summary
Enables protein kinase C binding activity. Involved in negative regulation of translation and regulation of protein localization to plasma membrane. Located in membrane. Part of small ribosomal subunit. Used to study transient cerebral ischemia. Orthologous to human RACK1 (receptor for activated C kinase 1). [provided by Alliance of Genome Resources, Feb 2025]
Expression
Biased expression in Spleen (RPKM 3301.3), Thymus (RPKM 2922.4) and 9 other tissues See more
Orthologs
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Genomic context

See Rack1 in Genome Data Viewer
Location:
10q21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (33668560..33676031)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (33169415..33174896)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (34149717..34155198)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L30, pseudogene 1 Neighboring gene histidyl-tRNA synthetase 2 like 1 Neighboring gene small nucleolar RNA SNORD95 Neighboring gene small nucleolar RNA, C/D box 96A Neighboring gene small nucleolar RNA, C/D box 95 Neighboring gene tripartite motif-containing 41 Neighboring gene transfer RNA valine (anticodon CAC) 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables BH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables SH2 domain binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ion channel inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables ion channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase C binding IC
Inferred by Curator
more info
PubMed 
enables protein kinase C binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables signaling adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in gastrulation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of translational frameshifting IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in osteoblast differentiation HDA PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in pigmentation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pigmentation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Golgi to plasma membrane protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
 
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of IRE1-RACK1-PP2A complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane HDA PubMed 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in phagocytic cup ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic cup ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
part_of small ribosomal subunit IEA
Inferred from Electronic Annotation
more info
 
part_of small ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
small ribosomal subunit protein RACK1
Names
guanine nucleotide binding protein (G protein) beta polypeptide 2-like 1
guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
guanine nucleotide binding protein, beta polypeptide 2-like 1
guanine nucleotide-binding protein subunit beta-2-like 1
protein kinase C receptor
receptor for activated protein kinase C
receptor of activated protein C kinase 1
receptor of activated protein kinase C 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130734.2NP_570090.2  small ribosomal subunit protein RACK1

    See identical proteins and their annotated locations for NP_570090.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P63245
    UniProtKB/TrEMBL
    A6HDT8
    Related
    ENSRNOP00000074147.1, ENSRNOT00000084232.3
    Conserved Domains (2) summary
    cd00200
    Location:7311
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:1861
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    33668560..33676031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269959.1XP_063126029.1  small ribosomal subunit protein RACK1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZE6