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FCRL4 Fc receptor like 4 [ Homo sapiens (human) ]

Gene ID: 83417, updated on 5-Nov-2022

Summary

Official Symbol
FCRL4provided by HGNC
Official Full Name
Fc receptor like 4provided by HGNC
Primary source
HGNC:HGNC:18507
See related
Ensembl:ENSG00000163518 MIM:605876; AllianceGenome:HGNC:18507
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FCRH4; IGFP2; IRTA1; CD307d
Summary
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
Expression
Biased expression in lymph node (RPKM 2.4), appendix (RPKM 2.3) and 5 other tissues See more
Orthologs
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Genomic context

See FCRL4 in Genome Data Viewer
Location:
1q23.1
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157573747..157598085, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156710808..156735121, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157543537..157567875, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SLAM family member 5 Neighboring gene Fc receptor like 5 Neighboring gene uncharacterized LOC105371457 Neighboring gene Fc receptor like 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of B cells with HIV-1 gp120 upregulates the expression of FCRL4 and limits the proliferative expansion of B cells in an integrin alpha 4/beta 7-dependent manner PubMed
env HIV-1 gp120-induced downregulation of CD80 and upregulation of FCRL4 involve the TGF-beta1 signaling pathway in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150522, MGC150523

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Fc receptor-like protein 4
Names
IFGP family protein 2
fc receptor homolog 4
fcR-like protein 4
hIFGP2
immune receptor translocation-associated protein 1
immunoglobulin superfamily Fc receptor, gp42
immunoglobulin superfamily receptor translocation associated 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031282.3NP_112572.1  Fc receptor-like protein 4 precursor

    See identical proteins and their annotated locations for NP_112572.1

    Status: REVIEWED

    Source sequence(s)
    AF343659, AF343661, AL135929
    Consensus CDS
    CCDS1166.1
    UniProtKB/Swiss-Prot
    Q96PJ5, Q96RE0
    Related
    ENSP00000271532.1, ENST00000271532.2
    Conserved Domains (4) summary
    cd05752
    Location:23100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:295377
    IG_like; Immunoglobulin like
    pfam13895
    Location:193281
    Ig_2; Immunoglobulin domain
    cd05753
    Location:105188
    Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    157573747..157598085 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510034.2XP_011508336.1  Fc receptor-like protein 4 isoform X1

    Conserved Domains (5) summary
    cd05752
    Location:2299
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:294376
    IG_like; Immunoglobulin like
    pfam00047
    Location:301369
    ig; Immunoglobulin domain
    pfam13927
    Location:192264
    Ig_3; Immunoglobulin domain
    cl11960
    Location:104170
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    156710808..156735121 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)