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Lamtor2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 [ Mus musculus (house mouse) ]

Gene ID: 83409, updated on 27-Nov-2024

Summary

Official Symbol
Lamtor2provided by MGI
Official Full Name
late endosomal/lysosomal adaptor, MAPK and MTOR activator 2provided by MGI
Primary source
MGI:MGI:1932697
See related
Ensembl:ENSMUSG00000028062 AllianceGenome:MGI:1932697
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P14; Rab25; Robld3; Mapbpip; 2010111E04Rik
Summary
Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Acts upstream of or within several processes, including fibroblast migration; positive regulation of MAPK cascade; and regulation of cell-substrate junction organization. Located in late endosome. Orthologous to human LAMTOR2 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney adult (RPKM 88.5), colon adult (RPKM 83.4) and 28 other tissues See more
Orthologs
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Genomic context

See Lamtor2 in Genome Data Viewer
Location:
3 F1; 3 38.87 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88457126..88460258, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88549819..88552951, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene mex3 RNA binding family member A Neighboring gene microRNA 1905 Neighboring gene RAB25, member RAS oncogene family Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88356947-88357056 Neighboring gene STARR-positive B cell enhancer ABC_E8803 Neighboring gene ubiquilin 4 Neighboring gene STARR-seq mESC enhancer starr_08200 Neighboring gene STARR-seq mESC enhancer starr_08201 Neighboring gene RNA transcription, translation and transport factor, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in TORC1 signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to amino acid stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within fibroblast migration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within fibroblast migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein localization to cell junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of cell-substrate junction organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell-substrate junction organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell-substrate junction organization ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
part_of FNIP-folliculin RagC/D GAP IEA
Inferred from Electronic Annotation
more info
 
part_of FNIP-folliculin RagC/D GAP ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Ragulator complex ISO
Inferred from Sequence Orthology
more info
 
part_of Ragulator complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ragulator complex protein LAMTOR2
Names
endosomal adaptor protein p14
late endosomal/lysosomal MP1 interacting protein
late endosomal/lysosomal adaptor and MAPK and MTOR activator 2
mitogen-activated protein-binding protein-interacting protein
roadblock domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362368.1NP_001349297.1  ragulator complex protein LAMTOR2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BE629197, BY062676
    Conserved Domains (1) summary
    pfam03259
    Location:877
    Robl_LC7; Roadblock/LC7 domain
  2. NM_031248.4NP_112538.1  ragulator complex protein LAMTOR2 isoform 1

    See identical proteins and their annotated locations for NP_112538.1

    Status: VALIDATED

    Source sequence(s)
    AA250375, BE947263, BY062676
    Consensus CDS
    CCDS17478.1
    UniProtKB/Swiss-Prot
    Q9JHS3
    Related
    ENSMUSP00000029698.9, ENSMUST00000029698.15
    Conserved Domains (1) summary
    pfam03259
    Location:595
    Robl_LC7; Roadblock/LC7 domain

RNA

  1. NR_155541.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145168
  2. NR_155542.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC145168
    Related
    ENSMUST00000156421.2
  3. NR_155543.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AW988728, BE947263, BY062676
    Related
    ENSMUST00000119002.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88457126..88460258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)