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UPM1 urophorphyrin methylase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834085, updated on 6-Oct-2023

Summary

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Gene symbol
UPM1
Gene description
urophorphyrin methylase 1
Primary source
Araport:AT5G40850
Locus tag
AT5G40850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
MHK7.8; MHK7_8; urophorphyrin methylase 1
Summary
Encodes a urophorphyrin III methylase that catalyzes S-adenosyl-L-methionine-dependent transmethylation in a multistep process involving the formation of a covalently linked complex with S-adenosyl-L-methionine.
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Genomic context

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See UPM1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (16365900..16369316)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Rad21/Rec8-like family protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uridine kinase/uracil phosphoribosyltransferase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alleviation of Nitrogen and Sulfur Deficiency and Enhancement of Photosynthesis in Arabidopsis thaliana by Overexpression of Uroporphyrinogen III Methyltransferase (UPM1). Garai S, et al. Front Plant Sci, 2017. PMID 29472934, Free PMC Article
  2. Phylogenetic analysis and photoregulation of siroheme biosynthesis genes: uroporphyrinogen III methyltransferase and sirohydrochlorin ferrochelatase of Arabidopsis thaliana. Garai S, et al. Physiol Mol Biol Plants, 2016 Jul. PMID 27729721, Free PMC Article
  3. Gene expression profiling of the tetrapyrrole metabolic pathway in Arabidopsis with a mini-array system. Matsumoto F, et al. Plant Physiol, 2004 Aug. PMID 15326282, Free PMC Article
  4. Siroheme biosynthesis in higher plants. Analysis of an S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransferase from Arabidopsis thaliana. Leustek T, et al. J Biol Chem, 1997 Jan 31. PMID 9006913
  5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

NM_001203515.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables uroporphyrin-III C-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of chlorophyll biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nitrate assimilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of sulfate assimilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within siroheme biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in siroheme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
urophorphyrin methylase 1
NP_001190444.1
  • urophorphyrin methylase 1 (UPM1); CONTAINS InterPro DOMAIN/s: Tetrapyrrole methylase (InterPro:IPR000878), Tetrapyrrole methylase, subdomain 1 (InterPro:IPR014777), Uroporphyrin-III C-methyltransferase, C-terminal (InterPro:IPR006366), Tetrapyrrole methylase, subdomain 2 (InterPro:IPR014776), Uroporphiryn-III C-methyltransferase, conserved site (InterPro:IPR003043).
NP_198901.1
  • urophorphyrin methylase 1 (UPM1); CONTAINS InterPro DOMAIN/s: Tetrapyrrole methylase (InterPro:IPR000878), Tetrapyrrole methylase, subdomain 1 (InterPro:IPR014777), Uroporphyrin-III C-methyltransferase, plant (InterPro:IPR012383), Uroporphyrin-III C-methyltransferase, C-terminal (InterPro:IPR006366), Tetrapyrrole methylase, subdomain 2 (InterPro:IPR014776), Uroporphiryn-III C-methyltransferase, conserved site (InterPro:IPR003043); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    16365900..16369316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123450.5 → NP_198901.1  urophorphyrin methylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198901.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42606, Q96532
    UniProtKB/TrEMBL
    A0A178UEZ5, A0A5S9YC46
    Conserved Domains (1) summary
    PLN02625
    Location:82 → 363
    PLN02625; uroporphyrin-III C-methyltransferase

  2. NM_001344363.1 → NP_001331463.1  urophorphyrin methylase 1 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BE13

  3. NM_001203515.1 → NP_001190444.1  urophorphyrin methylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001190444.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UEZ5, A0A5S9YC46, F4KIS7
    Conserved Domains (1) summary
    PLN02625
    Location:82 → 325
    PLN02625; uroporphyrin-III C-methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q42606.1

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