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ATR Ataxia telangiectasia-mutated and RAD3-like protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 834082, updated on 12-Aug-2018

Summary

Gene symbol
ATR
Gene description
Ataxia telangiectasia-mutated and RAD3-like protein
Primary source
Araport:AT5G40820
Locus tag
AT5G40820
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA ATAXIA TELANGIECTASIA-MUTATED AND RAD3-RELATED; ATATR; Ataxia telangiectasia-mutated and RAD3-related; ATRAD3; MHK7.5; MHK7_5
Summary
Encodes a Arabidopsis ortholog of the ATR protein kinase that is involved in a wide range of responses to DNA damage and plays a central role in cell-cycle regulation. Dominant loss of function alleles identified as suppressors of ALS also exhibit increased tolerance to aluminum. This may be due to the inhibition of terminal differentiation of the root apex upon exposure to Al.

Genomic context

See ATR in Genome Data Viewer
Location:
chromosome: 5
Exon count:
16
Sequence:
Chromosome: 5; NC_003076.8 (16342728..16353898, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene Cytochrome C1 family Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Rad21/Rec8-like family protein

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

NM_001344355.1
NM_001344356.1
NM_001344357.1
NM_123447.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA repair IGI
Inferred from Genetic Interaction
more info
PubMed 
double-strand break repair via nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism reproduction IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of chromosome organization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of telomere maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
response to aluminum ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
telomere maintenance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
telomere maintenance in response to DNA damage TAS
Traceable Author Statement
more info
PubMed 
telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISM
Inferred from Sequence Model
more info
 
plasmodesma IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Ataxia telangiectasia-mutated and RAD3-like protein
NP_198898.2
  • Ataxia telangiectasia-mutated and RAD3-related (ATR); FUNCTIONS IN: protein serine/threonine kinase activity, inositol or phosphatidylinositol kinase activity, binding, phosphotransferase activity, alcohol group as acceptor; INVOLVED IN: in 9 processes; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidylinositol 3-/4-kinase, catalytic (InterPro:IPR000403), UME (InterPro:IPR012993), Protein kinase-like domain (InterPro:IPR011009), PIK-related kinase, FAT (InterPro:IPR003151), Armadillo-type fold (InterPro:IPR016024), PIK-related kinase (InterPro:IPR014009), Phosphatidylinositol 3/4-kinase, conserved site (InterPro:IPR018936), PIK-related kinase, FATC (InterPro:IPR003152); BEST Arabidopsis thaliana protein match is: ataxia-telangiectasia mutated (TAIR:AT3G48190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    16342728..16353898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_123447.3NP_198898.2  Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_198898.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FKS4
    Conserved Domains (4) summary
    smart00802
    Location:10881194
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    cd00892
    Location:23632638
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
    pfam02259
    Location:17872165
    FAT; FAT domain
    pfam02260
    Location:26752702
    FATC; FATC domain
  2. NM_001344356.1NP_001332643.1  Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FKS4
    Conserved Domains (4) summary
    smart00802
    Location:10881194
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    cd00892
    Location:23632638
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
    pfam02259
    Location:17872165
    FAT; FAT domain
    pfam02260
    Location:26752702
    FATC; FATC domain
  3. NM_001344355.1NP_001332644.1  Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1R7T394
  4. NM_001344357.1NP_001332642.1  Ataxia telangiectasia-mutated and RAD3-like protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9FKS4
    Conserved Domains (4) summary
    smart00802
    Location:10881194
    UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    cd00892
    Location:23632638
    PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
    pfam02259
    Location:17872165
    FAT; FAT domain
    pfam02260
    Location:26752702
    FATC; FATC domain
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