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Akap12 A kinase anchor protein 12 [ Mus musculus (house mouse) ]

Gene ID: 83397, updated on 8-Feb-2024

Summary

Official Symbol
Akap12provided by MGI
Official Full Name
A kinase anchor protein 12provided by MGI
Primary source
MGI:MGI:1932576
See related
Ensembl:ENSMUSG00000038587 AllianceGenome:MGI:1932576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srcs5; SSeCKS; Tsga12
Summary
Predicted to enable adenylate cyclase binding activity. Involved in modulation of chemical synaptic transmission. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system; gut; neural ectoderm; renal interstitium; and retina. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 189.4), bladder adult (RPKM 35.0) and 6 other tissues See more
Orthologs
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Genomic context

See Akap12 in Genome Data Viewer
Location:
10 A1; 10 2.06 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4216329..4309471)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4266329..4359471)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25369 Neighboring gene predicted gene, 30570 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:6084769-6084970 Neighboring gene STARR-seq mESC enhancer starr_25646 Neighboring gene STARR-seq mESC enhancer starr_25645 Neighboring gene STARR-seq mESC enhancer starr_25640 Neighboring gene predicted gene, 40592 Neighboring gene STARR-seq mESC enhancer starr_25637 Neighboring gene STARR-positive B cell enhancer ABC_E11428 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5999414-5999597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5988889-5989072 Neighboring gene STARR-seq mESC enhancer starr_25630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:5958087-5958270 Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene STARR-positive B cell enhancer ABC_E2315 Neighboring gene acidic residue methyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor complex adaptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
A-kinase anchor protein 12
Names
A kinase (PRKA) anchor protein (gravin) 12
AKAP-12
gercelin
germ cell lineage protein gercelin
src-suppressed C kinase substrate
testis specific gene A12
v-src suppressed transcript 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031185.3NP_112462.1  A-kinase anchor protein 12

    See identical proteins and their annotated locations for NP_112462.1

    Status: VALIDATED

    Source sequence(s)
    AB051563, AI836130, CD540754
    Consensus CDS
    CCDS56673.1
    UniProtKB/Swiss-Prot
    Q80SS4, Q810D4, Q8BPK4, Q99MP1, Q9WTQ5
    UniProtKB/TrEMBL
    A0A668KLD3, A0A668KLV9, B2RRE0
    Related
    ENSMUSP00000035829.6, ENSMUST00000045730.7
    Conserved Domains (1) summary
    pfam03832
    Location:592619
    WSK; WSK motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    4216329..4309471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)