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Akap12 A kinase (PRKA) anchor protein (gravin) 12 [ Mus musculus (house mouse) ]

Gene ID: 83397, updated on 5-Jan-2022

Summary

Official Symbol
Akap12provided by MGI
Official Full Name
A kinase (PRKA) anchor protein (gravin) 12provided by MGI
Primary source
MGI:MGI:1932576
See related
Ensembl:ENSMUSG00000038587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srcs5; SSeCKS; Tsga12; AI317366
Summary
Predicted to enable adenylate cyclase binding activity. Involved in modulation of chemical synaptic transmission. Is active in Schaffer collateral - CA1 synapse. Is expressed in central nervous system; gut; neural ectoderm; renal interstitium; and retina. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis adult (RPKM 189.4), bladder adult (RPKM 35.0) and 6 other tissues See more
Orthologs
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Genomic context

See Akap12 in Genome Data Viewer
Location:
10; 10 A1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (4216329..4309471)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (4266329..4359471)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (5987070..6080212, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25369 Neighboring gene predicted gene, 30570 Neighboring gene predicted gene, 40592 Neighboring gene zinc finger and BTB domain containing 2 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene acidic residue methyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase A binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor complex adaptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of hepatic stellate cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric-oxide synthase biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase A signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein kinase C signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
A-kinase anchor protein 12
Names
AKAP-12
gercelin
germ cell lineage protein gercelin
src-suppressed C kinase substrate
testis specific gene A12
v-src suppressed transcript 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031185.3NP_112462.1  A-kinase anchor protein 12

    See identical proteins and their annotated locations for NP_112462.1

    Status: VALIDATED

    Source sequence(s)
    AB051563, AI836130, CD540754
    Consensus CDS
    CCDS56673.1
    UniProtKB/Swiss-Prot
    Q9WTQ5
    UniProtKB/TrEMBL
    B2RRE0
    Related
    ENSMUSP00000035829.6, ENSMUST00000045730.7
    Conserved Domains (1) summary
    pfam03832
    Location:592619
    WSK; WSK motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    4216329..4309471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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