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Siglece sialic acid binding Ig-like lectin E [ Mus musculus (house mouse) ]

Gene ID: 83382, updated on 17-Jan-2023

Summary

Official Symbol
Sigleceprovided by MGI
Official Full Name
sialic acid binding Ig-like lectin Eprovided by MGI
Primary source
MGI:MGI:1932475
See related
Ensembl:ENSMUSG00000030474 AllianceGenome:MGI:1932475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cd170; Siglec5; Siglec9; Siglec12; Siglecl1; mSiglec-E
Summary
Enables monosaccharide binding activity and sialic acid binding activity. Acts upstream of or within cell adhesion; negative regulation of inflammatory response; and negative regulation of phagocytosis, engulfment. Located in external side of plasma membrane. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to several human genes including SIGLEC8 (sialic acid binding Ig like lectin 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 9.7), liver E18 (RPKM 3.5) and 19 other tissues See more
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Genomic context

See Siglece in Genome Data Viewer
Location:
7 B3; 7
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43300494..43309585, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43648882..43672044, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 819 Neighboring gene CEA cell adhesion molecule 18 Neighboring gene uncharacterized LOC118567526 Neighboring gene cytosolic thiouridylase subunit 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables monosaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sialic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
sialic acid-binding Ig-like lectin 12
Names
MIS
SIGLEC-like 1
myeloid inhibitory siglec
sialic acid binding Ig-like lectin 5
sialic acid-binding Ig-like lectin-like 1
sialic acid-binding immunoglobulin-like lectin E
siglec-12
siglec-5
siglec-E
siglec-L1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031181.2NP_112458.2  sialic acid-binding Ig-like lectin 12 precursor

    See identical proteins and their annotated locations for NP_112458.2

    Status: VALIDATED

    Source sequence(s)
    AC151989
    Consensus CDS
    CCDS21178.1
    UniProtKB/Swiss-Prot
    E9QMD1, Q91Y57
    Related
    ENSMUSP00000032667.9, ENSMUST00000032667.10
    Conserved Domains (3) summary
    smart00408
    Location:270330
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:264339
    IG_like; Immunoglobulin like
    cl11960
    Location:25146
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43300494..43309585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541320.5XP_006541383.1  sialic acid-binding Ig-like lectin 12 isoform X3

    Conserved Domains (2) summary
    pfam13927
    Location:171233
    Ig_3; Immunoglobulin domain
    cl11960
    Location:25146
    Ig; Immunoglobulin domain
  2. XM_006541321.5XP_006541384.1  sialic acid-binding Ig-like lectin 12 isoform X4

    Conserved Domains (2) summary
    pfam13927
    Location:264326
    Ig_3; Immunoglobulin domain
    cl11960
    Location:25146
    Ig; Immunoglobulin domain
  3. XM_006541318.5XP_006541381.1  sialic acid-binding Ig-like lectin 12 isoform X1

    Conserved Domains (2) summary
    pfam13927
    Location:264326
    Ig_3; Immunoglobulin domain
    cl11960
    Location:25146
    Ig; Immunoglobulin domain
  4. XM_006541319.5XP_006541382.1  sialic acid-binding Ig-like lectin 12 isoform X2

    Conserved Domains (2) summary
    pfam13927
    Location:264326
    Ig_3; Immunoglobulin domain
    cl11960
    Location:25146
    Ig; Immunoglobulin domain