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H2AC14 H2A clustered histone 14 [ Homo sapiens (human) ]

Gene ID: 8331, updated on 23-Nov-2021

Summary

Official Symbol
H2AC14provided by HGNC
Official Full Name
H2A clustered histone 14provided by HGNC
Primary source
HGNC:HGNC:4727
See related
Ensembl:ENSG00000276368 MIM:602791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H2A/E; H2AFE; HIST1H2AJ; dJ160A22.4
Summary
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Orthologs
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Genomic context

See H2AC14 in Genome Data Viewer
Location:
6p22.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (27814302..27814777, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (27782080..27782555, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H2A clustered histone 13 Neighboring gene H3 clustered histone 10 Neighboring gene H2B clustered histone 14 Neighboring gene H4 clustered histone 11

Genomic regions, transcripts, and products

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat peptides bind core histones H2A, H2B, H3 and H4, and Tat protein recruits histone acetyltransferases to the HIV-1 LTR promoter leading to acetylation of histones H3 and H4, derepressing chromatin structure and increasing NFkappaB responsiveness PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
histone cluster 1, H2aj
Names
H2A histone family, member E
histone 1, H2aj
histone cluster 1 H2A family member j

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021066.3NP_066544.1  histone cluster 1, H2aj

    See identical proteins and their annotated locations for NP_066544.1

    Status: REVIEWED

    Source sequence(s)
    AL049822
    Consensus CDS
    CCDS4628.1
    UniProtKB/Swiss-Prot
    Q99878
    Related
    ENSP00000328484.4, ENST00000333151.5
    Conserved Domains (1) summary
    PTZ00017
    Location:1128
    PTZ00017; histone H2A; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    27814302..27814777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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