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FZD9 frizzled class receptor 9 [ Homo sapiens (human) ]

Gene ID: 8326, updated on 4-Jul-2021

Summary

Official Symbol
FZD9provided by HGNC
Official Full Name
frizzled class receptor 9provided by HGNC
Primary source
HGNC:HGNC:4047
See related
Ensembl:ENSG00000188763 MIM:601766
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FZD3; CD349
Summary
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD9 gene is located within the Williams syndrome common deletion region of chromosome 7, and heterozygous deletion of the FZD9 gene may contribute to the Williams syndrome phenotype. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See FZD9 in Genome Data Viewer
Location:
7q11.23
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (73433778..73436120)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (72848108..72850450)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 50 Neighboring gene RNA, U6 small nuclear 1080, pseudogene Neighboring gene FKBP prolyl isomerase family member 6 (inactive) Neighboring gene bromodomain adjacent to zinc finger domain 1B Neighboring gene RNA, U6 small nuclear 1198, pseudogene Neighboring gene BAF chromatin remodeling complex subunit BCL7B

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-activated receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in bone regeneration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in learning or memory IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitochondrial depolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of necroptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of skeletal muscle acetylcholine-gated channel clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ossification ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of canonical Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of postsynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of skeletal muscle acetylcholine-gated channel clustering ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in release of cytochrome c from mitochondria ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in filopodium membrane IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
frizzled-9
Names
frizzled 9, seven transmembrane spanning receptor
frizzled family receptor 9
frizzled homolog 9
fz-9
fzE6
hFz9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012028.1 RefSeqGene

    Range
    5000..7342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003508.3NP_003499.1  frizzled-9 precursor

    See identical proteins and their annotated locations for NP_003499.1

    Status: REVIEWED

    Source sequence(s)
    AC005049, U82169
    Consensus CDS
    CCDS5548.1
    UniProtKB/Swiss-Prot
    O00144
    Related
    ENSP00000345785.3, ENST00000344575.5
    Conserved Domains (2) summary
    cd15036
    Location:221542
    7tmF_FZD9; class F frizzled subfamily 9, member of 7-transmembrane G protein-coupled receptors
    cl02447
    Location:35161
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    73433778..73436120
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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