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FZD8 frizzled class receptor 8 [ Homo sapiens (human) ]

Gene ID: 8325, updated on 11-Jun-2021

Summary

Official Symbol
FZD8provided by HGNC
Official Full Name
frizzled class receptor 8provided by HGNC
Primary source
HGNC:HGNC:4046
See related
Ensembl:ENSG00000177283 MIM:606146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FZ-8; hFZ8
Summary
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See FZD8 in Genome Data Viewer
Location:
10p11.21
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (35638247..35642296, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (35927175..35931224, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984221 Neighboring gene gap junction protein delta 4 Neighboring gene VISTA enhancer hs1588 Neighboring gene uncharacterized LOC105376494 Neighboring gene microRNA 4683 Neighboring gene VISTA enhancer hs1567

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
GeneReviews: Not available
Genetically distinct subsets within ANCA-associated vasculitis.
GeneReviews: Not available
Genome-wide association study of periodontal pathogen colonization.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables Wnt-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
frizzled-8
Names
frizzled 8, seven transmembrane spanning receptor
frizzled family receptor 8
frizzled homolog 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029968.1 RefSeqGene

    Range
    5001..8186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_031866.3NP_114072.1  frizzled-8 precursor

    See identical proteins and their annotated locations for NP_114072.1

    Status: REVIEWED

    Source sequence(s)
    AL121749
    Consensus CDS
    CCDS7192.1
    UniProtKB/Swiss-Prot
    Q9H461
    Related
    ENSP00000363826.1, ENST00000374694.3
    Conserved Domains (2) summary
    cd07461
    Location:31155
    CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
    cd15250
    Location:267618
    7tmF_FZD8; class F frizzled subfamily 8, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    35638247..35642296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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