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FZD7 frizzled class receptor 7 [ Homo sapiens (human) ]

Gene ID: 8324, updated on 1-Jun-2020

Summary

Official Symbol
FZD7provided by HGNC
Official Full Name
frizzled class receptor 7provided by HGNC
Primary source
HGNC:HGNC:4045
See related
Ensembl:ENSG00000155760 MIM:603410
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FzE3
Summary
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See FZD7 in Genome Data Viewer
Location:
2q33.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (202034587..202038437)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202899310..202903160)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 15 Neighboring gene ubiquitin conjugating enzyme E2 V1 pseudogene 11 Neighboring gene RNA, U6 small nuclear 440, pseudogene Neighboring gene KIAA2012 antisense RNA 1 Neighboring gene KIAA2012 Neighboring gene proteasome subunit alpha 2 pseudogene 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Wnt-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-protein binding NAS
Non-traceable Author Statement
more info
PubMed 
frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
Wnt signaling pathway, planar cell polarity pathway TAS
Traceable Author Statement
more info
 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
mesenchymal to epithelial transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cardiac muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ectodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-canonical Wnt signaling pathway via JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade IC
Inferred by Curator
more info
PubMed 
positive regulation of epithelial cell proliferation involved in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell division IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
frizzled-7
Names
Frizzled, drosophila, homolog of, 7
frizzled 7, seven transmembrane spanning receptor
frizzled family receptor 7
frizzled homolog 7
fz-7
hFz7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003507.1NP_003498.1  frizzled-7 precursor

    See identical proteins and their annotated locations for NP_003498.1

    Status: REVIEWED

    Source sequence(s)
    AB017365
    Consensus CDS
    CCDS2351.1
    UniProtKB/Swiss-Prot
    O75084
    Related
    ENSP00000286201.1, ENST00000286201.2
    Conserved Domains (2) summary
    cd07466
    Location:45169
    CRD_FZ7; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 7 (Fz7) receptor
    cd15246
    Location:243573
    7tmF_FZD7; class F frizzled subfamily 7, member of 7-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    202034587..202038437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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