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FZD6 frizzled class receptor 6 [ Homo sapiens (human) ]

Gene ID: 8323, updated on 18-Aug-2020

Summary

Official Symbol
FZD6provided by HGNC
Official Full Name
frizzled class receptor 6provided by HGNC
Primary source
HGNC:HGNC:4044
See related
Ensembl:ENSG00000164930 MIM:603409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FZ6; FZ-6; HFZ6; NDNC1; NDNC10
Summary
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in thyroid (RPKM 15.4), lung (RPKM 14.1) and 25 other tissues See more
Orthologs

Genomic context

See FZD6 in Genome Data Viewer
Location:
8q22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (103298494..103332866)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (104310661..104345094)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene BAALC binder of MAP3K1 and KLF4 Neighboring gene BAALC antisense RNA 1 Neighboring gene microRNA 3151 Neighboring gene uncharacterized LOC105369147 Neighboring gene small nucleolar RNA, C/D box 173 Neighboring gene RNA, U6 small nuclear 1011, pseudogene Neighboring gene collagen triple helix repeat containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of FZD6 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Wnt-activated receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Wnt-protein binding NAS
Non-traceable Author Statement
more info
PubMed 
NOT amyloid-beta binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, planar cell polarity pathway NAS
Non-traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell proliferation in midbrain IEA
Inferred from Electronic Annotation
more info
 
embryonic nail plate morphogenesis IEA
Inferred from Electronic Annotation
more info
 
establishment of body hair planar orientation IEA
Inferred from Electronic Annotation
more info
 
hair follicle development IEA
Inferred from Electronic Annotation
more info
 
inner ear morphogenesis IEA
Inferred from Electronic Annotation
more info
 
midbrain morphogenesis TAS
Traceable Author Statement
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube closure IEA
Inferred from Electronic Annotation
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
apicolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
frizzled-6
Names
frizzled 6, seven transmembrane spanning receptor
frizzled family receptor 6
frizzled homolog 6
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028909.2 RefSeqGene

    Range
    2905..36873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164615.2NP_001158087.1  frizzled-6 isoform a precursor

    See identical proteins and their annotated locations for NP_001158087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC025370
    Consensus CDS
    CCDS6298.1
    UniProtKB/Swiss-Prot
    O60353
    UniProtKB/TrEMBL
    A0A024R9E9
    Related
    ENSP00000429055.1, ENST00000522566.5
    Conserved Domains (2) summary
    cd07450
    Location:20146
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    pfam01534
    Location:189507
    Frizzled; Frizzled/Smoothened family membrane region
  2. NM_001164616.2NP_001158088.1  frizzled-6 isoform b

    See identical proteins and their annotated locations for NP_001158088.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a segment of the 5' UTR and 5' coding region, and uses a downstream translational start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC025370
    Consensus CDS
    CCDS55268.1
    UniProtKB/Swiss-Prot
    O60353
    Related
    ENSP00000429528.1, ENST00000523739.5
    Conserved Domains (2) summary
    cd07450
    Location:1114
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    pfam01534
    Location:157475
    Frizzled; Frizzled/Smoothened family membrane region
  3. NM_001317796.2NP_001304725.1  frizzled-6 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate translation start site and lacks an alternate exon in the 5' coding region compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus compared to isoform a. This isoform (c) lacks a predicted signal peptide compared to isoform a.
    Source sequence(s)
    AC025370
    UniProtKB/Swiss-Prot
    O60353
    UniProtKB/TrEMBL
    B4DL33
    Conserved Domains (1) summary
    pfam01534
    Location:9202
    Frizzled; Frizzled/Smoothened family membrane region
  4. NM_003506.4NP_003497.2  frizzled-6 isoform a precursor

    See identical proteins and their annotated locations for NP_003497.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC025370
    Consensus CDS
    CCDS6298.1
    UniProtKB/Swiss-Prot
    O60353
    UniProtKB/TrEMBL
    A0A024R9E9, B4E236
    Related
    ENSP00000351605.4, ENST00000358755.5
    Conserved Domains (2) summary
    cd07450
    Location:20146
    CRD_FZ6; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 6 (Fz6) receptor
    pfam01534
    Location:189507
    Frizzled; Frizzled/Smoothened family membrane region

RNA

  1. NR_133921.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC025370
    Related
    ENST00000522484.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    103298494..103332866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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