S1P SITE-1 protease [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: S1P
Gene description: SITE-1 protease
Primary source: Araport:AT5G19660
Locus tag: AT5G19660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATS1P; ATSBT6.1; SITE-1 protease; SITE-1 PROTEASE; T29J13.80; T29J13_80
Summary: S1P appears to function as a Golgi-localized subtilase and to help protect seedlings against salt and osmotic stress. The roots of s1p-3 mutants are hypersensitive to NaCl, KCl, LiCl, and mannitol. Several salt-stress responsive genes show weaker induction in an s1P-3 mutant background. The proteolytic cleavage of the bZIP17 transcription factor depends on S1P in vitro. And there is evidence that S1P can cleave bZIP17 in vitro.
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Genomic context

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See S1P in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 10

Sequence:: Chromosome: 5; NC_003076.8 (6641907..6646550, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The GLV1 precursor is a direct subtilase substrate. The elimination of the in vitro subtilase recognition sites through alanine substitution suppressed the GLV1 gain-of-function phenotype in vivo. The protease inhibitor Serpin1 bound to SBT6.1 and inhibited the cleavage of GLV1 precursors by the protease.
Title: The SBT6.1 subtilase processes the GOLVEN1 peptide controlling cell elongation.
required for cleaving bZIP17 in response to salt stress
Title: Salt stress responses in Arabidopsis utilize a signal transduction pathway related to endoplasmic reticulum stress signaling.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001343619.1

Supported by ESTs:

NM_001343620.1

Supported by ESTs:

NM_121971.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hyperosmotic salinity response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in extracellular region	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: SITE-1 protease

NP_197467.1

SITE-1 protease (S1P); CONTAINS InterPro DOMAIN/s: Peptidase S8/S53, subtilisin/kexin/sedolisin (InterPro:IPR000209), Peptidase S8, subtilisin-related (InterPro:IPR015500), Peptidase S8/S53, subtilisin, active site (InterPro:IPR022398); BEST Arabidopsis thaliana protein match is: Subtilisin-like serine endopeptidase family protein (TAIR:AT1G20160.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

6641907..6646550 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_121971.3 → NP_197467.1 SITE-1 protease [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197467.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0WUG6, Q8L7B7

UniProtKB/TrEMBL

A0A178UNR0, A0A5S9Y5X5

Conserved Domains (1) summary

cd07479
Location:197 → 453

Peptidases_S8_SKI-1_like; Peptidase S8 family domain in SKI-1-like proteins
NM_001343620.1 → NP_001331147.1 SITE-1 protease [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BD04
NM_001343619.1 → NP_001331146.1 SITE-1 protease [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8BD04