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CDC45 cell division cycle 45 [ Homo sapiens (human) ]

Gene ID: 8318, updated on 13-Mar-2020

Summary

Official Symbol
CDC45provided by HGNC
Official Full Name
cell division cycle 45provided by HGNC
Primary source
HGNC:HGNC:1739
See related
Ensembl:ENSG00000093009 MIM:603465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDC45L; MGORS7; CDC45L2; PORC-PI-1
Summary
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression
Biased expression in testis (RPKM 11.5), bone marrow (RPKM 6.8) and 11 other tissues See more
Orthologs

Genomic context

See CDC45 in Genome Data Viewer
Location:
22q11.21
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (19479294..19520612)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (19466984..19508135)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372860 Neighboring gene chromosome 22 open reading frame 39 Neighboring gene ubiquitin recognition factor in ER associated degradation 1 Neighboring gene claudin 5 Neighboring gene long intergenic non-protein coding RNA 895

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
DNA replication checkpoint TAS
Traceable Author Statement
more info
PubMed 
DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of chromatin silencing at telomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear pre-replicative complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cell division control protein 45 homolog
Names
CDC45 cell division cycle 45 homolog
CDC45 cell division cycle 45-like
CDC45-related protein
cell division cycle 45 homolog
cell division cycle 45-like 2
human CDC45

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052958.1 RefSeqGene

    Range
    5001..45787
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178010.2NP_001171481.1  cell division control protein 45 homolog isoform 1

    See identical proteins and their annotated locations for NP_001171481.1

    Status: REVIEWED

    Source sequence(s)
    AC000088, AF081535, AK293338, HY016491
    Consensus CDS
    CCDS54499.1
    UniProtKB/Swiss-Prot
    O75419
    Related
    ENSP00000405726.2, ENST00000437685.6
    Conserved Domains (1) summary
    pfam02724
    Location:19593
    CDC45; CDC45-like protein
  2. NM_001178011.2NP_001171482.1  cell division control protein 45 homolog isoform 3

    See identical proteins and their annotated locations for NP_001171482.1

    Status: REVIEWED

    Source sequence(s)
    AC000087, AF081535, AK293123, HY016491
    Consensus CDS
    CCDS54500.1
    UniProtKB/Swiss-Prot
    O75419
    Related
    ENSP00000384978.3, ENST00000404724.7
    Conserved Domains (1) summary
    pfam02724
    Location:19515
    CDC45; CDC45-like protein
  3. NM_001369291.1NP_001356220.1  cell division control protein 45 homolog isoform 4 precursor

    Status: REVIEWED

    Source sequence(s)
    AC000082, AC000087, AC000088
    Conserved Domains (1) summary
    pfam02724
    Location:7549
    CDC45; CDC45-like protein
  4. NM_003504.5NP_003495.1  cell division control protein 45 homolog isoform 2

    See identical proteins and their annotated locations for NP_003495.1

    Status: REVIEWED

    Source sequence(s)
    AC000082, AC000087, AC000088
    Consensus CDS
    CCDS13762.1
    UniProtKB/Swiss-Prot
    O75419
    Related
    ENSP00000263201.1, ENST00000263201.6
    Conserved Domains (1) summary
    pfam02724
    Location:19561
    CDC45; CDC45-like protein

RNA

  1. NR_161281.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC000082, AC000087, AC000088
    Related
    ENST00000672837.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

    Range
    19479294..19520612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530417.3XP_011528719.1  cell division control protein 45 homolog isoform X4

    Conserved Domains (1) summary
    pfam02724
    Location:19516
    CDC45; CDC45-like protein
  2. XM_011530418.3XP_011528720.1  cell division control protein 45 homolog isoform X5

    See identical proteins and their annotated locations for XP_011528720.1

    UniProtKB/Swiss-Prot
    O75419
    Conserved Domains (1) summary
    pfam02724
    Location:19515
    CDC45; CDC45-like protein
  3. XM_011530416.1XP_011528718.1  cell division control protein 45 homolog isoform X2

    Conserved Domains (1) summary
    pfam02724
    Location:7550
    CDC45; CDC45-like protein
  4. XM_024452277.1XP_024308045.1  cell division control protein 45 homolog isoform X1

    Conserved Domains (1) summary
    pfam02724
    Location:19562
    CDC45; CDC45-like protein
  5. XM_017028966.1XP_016884455.1  cell division control protein 45 homolog isoform X6

    Related
    ENSP00000385240.2, ENST00000407835.6
    Conserved Domains (1) summary
    pfam02724
    Location:4392
    CDC45; CDC45-like protein
  6. XM_017028967.1XP_016884456.1  cell division control protein 45 homolog isoform X7

    Related
    ENSP00000500838.1, ENST00000671972.1

RNA

  1. XR_002958716.1 RNA Sequence

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