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CDC7 cell division cycle 7 [ Homo sapiens (human) ]

Gene ID: 8317, updated on 11-Sep-2019

Summary

Official Symbol
CDC7provided by HGNC
Official Full Name
cell division cycle 7provided by HGNC
Primary source
HGNC:HGNC:1745
See related
Ensembl:ENSG00000097046 MIM:603311
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Hsk1; CDC7L1; HsCDC7; huCDC7
Summary
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected. [provided by RefSeq, Aug 2008]
Expression
Broad expression in testis (RPKM 10.5), lymph node (RPKM 4.8) and 19 other tissues See more
Orthologs

Genomic context

See CDC7 in Genome Data Viewer
Location:
1p22.1
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (91498968..91525764)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (91966338..91991321)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985417 Neighboring gene uncharacterized LOC105378856 Neighboring gene uncharacterized LOC102723436 Neighboring gene WD repeat domain 82 pseudogene 2 Neighboring gene ribosomal protein L39 pseudogene 13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of optic disc parameters.
NHGRI GWA Catalog
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
NHGRI GWA Catalog

Pathways from BioSystems

  • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
    Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
  • Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
    Activation of the pre-replicative complex, organism-specific biosystemIn S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding b...
  • Cell Cycle, organism-specific biosystem (from WikiPathways)
    Cell Cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
    Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Cell cycle, organism-specific biosystem (from KEGG)
    Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • Cell cycle, conserved biosystem (from KEGG)
    Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
  • DNA Replication, organism-specific biosystem (from REACTOME)
    DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
  • DNA Replication, organism-specific biosystem (from WikiPathways)
    DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
  • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
    DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
  • G1/S Transition, organism-specific biosystem (from REACTOME)
    G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
  • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
    G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
  • M/G1 Transition, organism-specific biosystem (from REACTOME)
    M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
  • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
    Mitotic G1-G1/S phases, organism-specific biosystem
    Mitotic G1-G1/S phases
  • Retinoblastoma (RB) in Cancer, organism-specific biosystem (from WikiPathways)
    Retinoblastoma (RB) in Cancer, organism-specific biosystemDescribes the role of retinoblastoma (RB) gene in cancer.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117361, MGC126237, MGC126238

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of G0 to G1 transition TAS
Traceable Author Statement
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of nuclear cell cycle DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
intercellular bridge IDA
Inferred from Direct Assay
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cell division cycle 7-related protein kinase
Names
CDC7 (cell division cycle 7, S. cerevisiae, homolog)-like 1
CDC7-related kinase
cell division cycle 7 homolog
cell division cycle 7-like protein 1
epididymis secretory sperm binding protein
NP_001127891.1
NP_001127892.1
NP_003494.1
XP_005271298.1
XP_005271301.1
XP_016857914.1
XP_016857915.1
XP_016857916.1
XP_024305857.1
XP_024305858.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134419.1NP_001127891.1  cell division cycle 7-related protein kinase

    See identical proteins and their annotated locations for NP_001127891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI672674, BC110526, BC111044, DA791490, N62245
    Consensus CDS
    CCDS734.1
    UniProtKB/Swiss-Prot
    O00311
    Conserved Domains (2) summary
    cd14019
    Location:56438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293419
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001134420.1NP_001127892.1  cell division cycle 7-related protein kinase

    See identical proteins and their annotated locations for NP_001127892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different segment for part of its 5' UTR, compared to variant 1. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI672674, AK312726, BC111044, DA127303, N62245
    Consensus CDS
    CCDS734.1
    UniProtKB/Swiss-Prot
    O00311
    UniProtKB/TrEMBL
    B2R6V2
    Related
    ENSP00000393139.1, ENST00000428239.5
    Conserved Domains (2) summary
    cd14019
    Location:56438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293419
    PKc_like; Protein Kinases, catalytic domain
  3. NM_003503.4NP_003494.1  cell division cycle 7-related protein kinase

    See identical proteins and their annotated locations for NP_003494.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the most commonly occurring transcript. Variants 1, 2, and 3 all encode the same protein.
    Source sequence(s)
    AI672674, BC111044, DA791490, N62245
    Consensus CDS
    CCDS734.1
    UniProtKB/Swiss-Prot
    O00311
    Related
    ENSP00000234626.6, ENST00000234626.11
    Conserved Domains (2) summary
    cd14019
    Location:56438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293419
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    91498968..91525764
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450089.1XP_024305857.1  cell division cycle 7-related protein kinase isoform X1

    Conserved Domains (2) summary
    cd14019
    Location:56438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293419
    PKc_like; Protein Kinases, catalytic domain
  2. XM_005271241.2XP_005271298.1  cell division cycle 7-related protein kinase isoform X1

    See identical proteins and their annotated locations for XP_005271298.1

    UniProtKB/Swiss-Prot
    O00311
    Conserved Domains (2) summary
    cd14019
    Location:56438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293419
    PKc_like; Protein Kinases, catalytic domain
  3. XM_017002425.2XP_016857914.1  cell division cycle 7-related protein kinase isoform X2

    Conserved Domains (3) summary
    cd14019
    Location:56406
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    pfam00069
    Location:58417
    Pkinase; Protein kinase domain
    cl21453
    Location:314537
    PKc_like; Protein Kinases, catalytic domain
  4. XM_005271244.3XP_005271301.1  cell division cycle 7-related protein kinase isoform X2

    Conserved Domains (3) summary
    cd14019
    Location:56406
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    pfam00069
    Location:58417
    Pkinase; Protein kinase domain
    cl21453
    Location:314537
    PKc_like; Protein Kinases, catalytic domain
  5. XM_017002427.2XP_016857916.1  cell division cycle 7-related protein kinase isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:1321
    PKc_like; Protein Kinases, catalytic domain
  6. XM_017002426.1XP_016857915.1  cell division cycle 7-related protein kinase isoform X2

    Conserved Domains (3) summary
    cd14019
    Location:56406
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    pfam00069
    Location:58417
    Pkinase; Protein kinase domain
    cl21453
    Location:314537
    PKc_like; Protein Kinases, catalytic domain
  7. XM_024450090.1XP_024305858.1  cell division cycle 7-related protein kinase isoform X1

    Conserved Domains (2) summary
    cd14019
    Location:56438
    STKc_Cdc7; Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase
    cl21453
    Location:293419
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001737462.1 RNA Sequence

  2. XR_001737461.1 RNA Sequence

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