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TFL2 uncharacterized protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831635, updated on 4-Feb-2026
Official Symbol
TFL2
Official Full Name
uncharacterized protein
Primary source
TAIR:AT5G17690
Locus tag
AT5G17690
See related
Araport:AT5G17690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtLHP1; LHP1; LIKE HETEROCHROMATIN PROTEIN 1; MVA3.4; MVA3_4; TERMINAL FLOWER 2
Summary
Regulates the meristem response to light signals and the maintenance of inflorescence meristem identity. Influences developmental processes controlled by APETALA1. TFL2 silences specific genes within euchromatin but not genes positioned in heterochromatin. TFL2 protein localized preferentially to euchromatic regions and not to heterochromatic chromocenters. Involved in euchromatin organization. Required for epigenetic maintenance of the vernalized state.
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See TFL2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Sequence:
Chromosome: 5; NC_003076.8 (5827142..5829763, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene glycine/proline-rich protein Neighboring gene tRNA (guanine-N-7) methyltransferase Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene disease resistance protein (TIR-NBS-LRR class) Neighboring gene MATE efflux family protein Neighboring gene ncRNA

Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. DamID, a new tool for studying plant chromatin profiling in vivo, and its use to identify putative LHP1 target loci. Germann S, et al. Plant J, 2006 Oct. PMID 16972870
  2. Arabidopsis thaliana TERMINAL FLOWER2 is involved in light-controlled signalling during seedling photomorphogenesis. Valdés AE, et al. Plant Cell Environ, 2012 Jun. PMID 22145973
  3. TFL2/LHP1 is involved in auxin biosynthesis through positive regulation of YUCCA genes. Rizzardi K, et al. Plant J, 2011 Mar. PMID 21251106
  4. LHP1 Regulates H3K27me3 Spreading and Shapes the Three-Dimensional Conformation of the Arabidopsis Genome. Veluchamy A, et al. PLoS One, 2016. PMID 27410265, Free PMC Article
  5. The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation. Zhang X, et al. Nat Struct Mol Biol, 2007 Sep. PMID 17676062

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) partially inhibits the transcriptional activation of FT by MYB73 and regulates flowering in Arabidopsis.
    Title: LIKE HETEROCHROMATIN PROTEIN 1 (LHP1) partially inhibits the transcriptional activation of FT by MYB73 and regulates flowering in Arabidopsis.
  2. Interaction of ubiquitin-like protein SILENCING DEFECTIVE 2 with LIKE HETEROCHROMATIN PROTEIN 1 is required for regulation of anthocyanin biosynthesis in Arabidopsis thaliana in response to sucrose.
    Title: Interaction of ubiquitin-like protein SILENCING DEFECTIVE 2 with LIKE HETEROCHROMATIN PROTEIN 1 is required for regulation of anthocyanin biosynthesis in Arabidopsis thaliana in response to sucrose.
  3. SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana.
    Title: SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana.
  4. Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain.
    Title: Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain.
  5. Nuclear import of LIKE HETEROCHROMATIN PROTEIN1 is redundantly mediated by importins alpha-1, alpha-2 and alpha-3.
    Title: Nuclear import of LIKE HETEROCHROMATIN PROTEIN1 is redundantly mediated by importins α-1, α-2 and α-3.
  6. Arabidopsis PEAPODs function with LIKE HETEROCHROMATIN PROTEIN1 to regulate lateral organ growth.
    Title: Arabidopsis PEAPODs function with LIKE HETEROCHROMATIN PROTEIN1 to regulate lateral organ growth.
  7. EOL1 interacts with LHP1-PRC2 complexes during replication and thereby participates in maintaining the H3K27me3 mark at target genes.
    Title: Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana.
  8. a general role of LHP1 from local to higher conformation levels of chromatin configuration to determine its accessibility to define gene expression patterns
    Title: LHP1 Regulates H3K27me3 Spreading and Shapes the Three-Dimensional Conformation of the Arabidopsis Genome.
  9. Neither PRC2 activity nor LHP1 function are a major determinant for H2A monoubiquitination in Arabidopsis thaliana.
    Title: H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity.
  10. that complexes of the transcription factors ASYMMETRIC LEAVES 1 (AS1) and AS2 could help to establish the H3K27me3 modification at the chromatin regions of Class-I KNOTTED1-like homeobox (KNOX) genes BREVIPEDICELLUS and KNAT2 via direct interactions with LHP1.
    Title: Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis.
Submit: New GeneRIF Correction See all GeneRIFs (27)
Products Interactant Other Gene Complex Source Pubs Description
NM_001343518.1
NM_001343519.1
NM_121775.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
NOT enables 3,4-dihydroxy-2-butanone-4-phosphate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP cyclohydrolase II activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K27me3 reader activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gene expression, epigenetic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoperiodism IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within photoperiodism, flowering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to sucrose IEP
Inferred from Expression Pattern
more info
 PubMed 
NOT involved_in root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within shoot system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vernalization response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
Preferred Names
uncharacterized protein
NP_001330016.1
  • like heterochromatin protein (LHP1)
NP_001330017.1
  • like heterochromatin protein (LHP1)
NP_197271.1
  • TERMINAL FLOWER 2 (TFL2); CONTAINS InterPro DOMAIN/s: Chromo domain subgroup (InterPro:IPR017984), Chromo domain-like (InterPro:IPR016197), Chromo shadow, subgroup (InterPro:IPR018125), Chromo domain (InterPro:IPR000953); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).; like heterochromatin protein (LHP1)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    5827142..5829763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121775.3 → NP_197271.1  uncharacterized protein AT5G17690 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_197271.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q946J8, Q9FN82
    UniProtKB/TrEMBL
    A0A5S9Y7B5, Q058P7
    Conserved Domains (2) summary
    smart00298
    Location:107 → 156
    CHROMO; Chromatin organization modifier domain
    cd00034
    Location:385 → 442
    ChSh; Chromo Shadow Domain, found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g. ...

  2. NM_001343518.1 → NP_001330017.1  uncharacterized protein AT5G17690 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B9G6, A0A5S9Y7B5

  3. NM_001343519.1 → NP_001330016.1  uncharacterized protein AT5G17690 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178UDN2, A0A1P8B9H0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q946J8.2

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