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RGLG2 RING domain ligase2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 831293, updated on 4-Feb-2026
Official Symbol
RGLG2
Official Full Name
RING domain ligase2
Primary source
TAIR:AT5G14420
Locus tag
AT5G14420
See related
Araport:AT5G14420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F18O22.210; F18O22_210; RING domain ligase2
Summary
Encodes RGLG2 (RING domain ligase 2), a RING domain ubiquitin E3 ligase that negatively regulates the drought stress response by mediating ERF53 transcriptional activity.
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See RGLG2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Sequence:
Chromosome: 5; NC_003076.8 (4648081..4651442, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 724, subfamily A, polypeptide 1 Neighboring gene uncharacterized protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Surfeit locus protein 2 (SURF2) Neighboring gene ncRNA

Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2). Pan IC, et al. Mol Cell Proteomics, 2015 Oct. PMID 26253232, Free PMC Article
  2. RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis. Yu J, et al. J Integr Plant Biol, 2021 Mar. PMID 32970364
  3. Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response. Cheng MC, et al. Plant Physiol, 2012 Jan. PMID 22095047, Free PMC Article
  4. Ubiquitin lysine 63 chain forming ligases regulate apical dominance in Arabidopsis. Yin XJ, et al. Plant Cell, 2007 Jun. PMID 17586653, Free PMC Article
  5. Functional analysis of the RING-type ubiquitin ligase family of Arabidopsis. Stone SL, et al. Plant Physiol, 2005 Jan. PMID 15644464, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis.
    Title: RING finger protein RGLG1 and RGLG2 negatively modulate MAPKKK18 mediated drought stress tolerance in Arabidopsis.
  2. Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2
    Title: Post-Transcriptional Coordination of the Arabidopsis Iron Deficiency Response is Partially Dependent on the E3 Ligases RING DOMAIN LIGASE1 (RGLG1) and RING DOMAIN LIGASE2 (RGLG2).
  3. RGLG2 negatively regulates the drought stress response by mediating AtERF53 transcriptional activity in Arabidopsis.
    Title: Arabidopsis RGLG2, functioning as a RING E3 ligase, interacts with AtERF53 and negatively regulates the plant drought stress response.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description
NM_121446.5
NM_180487.4
NM_203050.3
NM_203051.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within auxin metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within cytokinin metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of response to water deprivation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
RING domain ligase2
NP_196946.1
  • RING domain ligase2 (RGLG2); FUNCTIONS IN: ubiquitin-protein ligase activity; INVOLVED IN: N-terminal protein myristoylation, cytokinin metabolic process, auxin metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 2368 Blast hits to 2301 proteins in 208 species: Archae - 0; Bacteria - 31; Metazoa - 1318; Fungi - 57; Plants - 528; Viruses - 55; Other Eukaryotes - 379 (source: NCBI BLink).
NP_850818.1
  • RING domain ligase2 (RGLG2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 2368 Blast hits to 2301 proteins in 208 species: Archae - 0; Bacteria - 31; Metazoa - 1318; Fungi - 57; Plants - 528; Viruses - 55; Other Eukaryotes - 379 (source: NCBI BLink).
NP_974779.1
  • RING domain ligase2 (RGLG2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_974780.1
  • RING domain ligase2 (RGLG2); CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Copine (InterPro:IPR010734), von Willebrand factor, type A (InterPro:IPR002035); BEST Arabidopsis thaliana protein match is: RING domain ligase1 (TAIR:AT3G01650.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    4648081..4651442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_203051.3 → NP_974780.1  RING domain ligase2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974780.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LY87
    UniProtKB/TrEMBL
    B9DGM7
    Conserved Domains (2) summary
    pfam13920
    Location:421 → 464
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl00057
    Location:99 → 349
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. NM_121446.5 → NP_196946.1  RING domain ligase2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196946.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LY87
    UniProtKB/TrEMBL
    B9DGM7
    Conserved Domains (2) summary
    pfam13920
    Location:421 → 464
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl00057
    Location:99 → 349
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. NM_203050.3 → NP_974779.1  RING domain ligase2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974779.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LY87
    UniProtKB/TrEMBL
    B9DGM7
    Conserved Domains (2) summary
    pfam13920
    Location:421 → 464
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl00057
    Location:99 → 349
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. NM_180487.4 → NP_850818.1  RING domain ligase2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850818.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LY87
    UniProtKB/TrEMBL
    B9DGM7
    Conserved Domains (2) summary
    pfam13920
    Location:421 → 464
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl00057
    Location:99 → 349
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LY87.1

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