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ACOX3 acyl-CoA oxidase 3, pristanoyl [ Homo sapiens (human) ]

Gene ID: 8310, updated on 1-Jun-2020

Summary

Official Symbol
ACOX3provided by HGNC
Official Full Name
acyl-CoA oxidase 3, pristanoylprovided by HGNC
Primary source
HGNC:HGNC:121
See related
Ensembl:ENSG00000087008 MIM:603402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in esophagus (RPKM 3.5), skin (RPKM 3.1) and 25 other tissues See more
Orthologs

Genomic context

See ACOX3 in Genome Data Viewer
Location:
4p16.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (8366263..8440723, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (8368009..8442452, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene HtrA serine peptidase 3 Neighboring gene uncharacterized LOC112268463 Neighboring gene long intergenic non-protein coding RNA 2517 Neighboring gene RNA, 5S ribosomal pseudogene 152 Neighboring gene uncharacterized LOC105374376 Neighboring gene tRNA methyltransferase 44 homolog Neighboring gene Sharpr-MPRA regulatory region 4448 Neighboring gene G protein-coupled receptor 78

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD binding IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pristanoyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid beta-oxidation using acyl-CoA oxidase IEA
Inferred from Electronic Annotation
more info
 
fatty acid beta-oxidation using acyl-CoA oxidase TAS
Traceable Author Statement
more info
 
lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
peroxisomal matrix TAS
Traceable Author Statement
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisomal acyl-coenzyme A oxidase 3
Names
BRCACox
acyl-Coenzyme A oxidase 3, pristanoyl
branched-chain acyl-CoA oxidase
pristanoyl-CoA oxidase
NP_001095137.1
NP_001362712.1
NP_001362713.1
NP_001362714.1
NP_001362715.1
NP_001362716.1
NP_001362717.1
NP_001362718.1
NP_001362719.1
NP_003492.2
XP_011511867.1
XP_011511868.1
XP_024310005.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101667.2NP_001095137.1  peroxisomal acyl-coenzyme A oxidase 3 isoform b

    See identical proteins and their annotated locations for NP_001095137.1

    Status: VALIDATED

    Source sequence(s)
    AC104825
    Consensus CDS
    CCDS47017.1
    UniProtKB/Swiss-Prot
    O15254
    Related
    ENSP00000413994.2, ENST00000413009.6
    Conserved Domains (1) summary
    cd01150
    Location:19609
    AXO; Peroxisomal acyl-CoA oxidase
  2. NM_001375783.1NP_001362712.1  peroxisomal acyl-coenzyme A oxidase 3 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC104825
    Related
    ENSP00000421625.1, ENST00000503233.5
  3. NM_001375784.1NP_001362713.1  peroxisomal acyl-coenzyme A oxidase 3 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC104825
  4. NM_001375785.1NP_001362714.1  peroxisomal acyl-coenzyme A oxidase 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC104825
  5. NM_001375786.1NP_001362715.1  peroxisomal acyl-coenzyme A oxidase 3 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC104825
  6. NM_001375787.1NP_001362716.1  peroxisomal acyl-coenzyme A oxidase 3 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC104825
  7. NM_001375788.1NP_001362717.1  peroxisomal acyl-coenzyme A oxidase 3 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC104825
  8. NM_001375789.1NP_001362718.1  peroxisomal acyl-coenzyme A oxidase 3 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC104825
  9. NM_001375790.1NP_001362719.1  peroxisomal acyl-coenzyme A oxidase 3 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC104825
  10. NM_003501.3NP_003492.2  peroxisomal acyl-coenzyme A oxidase 3 isoform a

    See identical proteins and their annotated locations for NP_003492.2

    Status: VALIDATED

    Source sequence(s)
    BC017053, CA306669, DA949869, Y11411
    Consensus CDS
    CCDS3401.1
    UniProtKB/Swiss-Prot
    O15254
    Related
    ENSP00000348775.4, ENST00000356406.10
    Conserved Domains (2) summary
    cd01150
    Location:19672
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02312
    Location:28655
    PLN02312; acyl-CoA oxidase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    8366263..8440723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513566.1XP_011511868.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X3

    Conserved Domains (1) summary
    cd01150
    Location:19591
    AXO; Peroxisomal acyl-CoA oxidase
  2. XM_011513565.2XP_011511867.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X1

    See identical proteins and their annotated locations for XP_011511867.1

    UniProtKB/Swiss-Prot
    O15254
    Conserved Domains (2) summary
    cd01150
    Location:19672
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02312
    Location:28655
    PLN02312; acyl-CoA oxidase
  3. XM_024454237.1XP_024310005.1  peroxisomal acyl-coenzyme A oxidase 3 isoform X4

    Conserved Domains (1) summary
    cl09933
    Location:19476
    ACAD; Acyl-CoA dehydrogenase

RNA

  1. XR_925000.1 RNA Sequence

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