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MES5 methyl esterase 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830894, updated on 18-Sep-2024

Summary

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Official Symbol
MES5
Official Full Name
methyl esterase 5
Primary source
TAIR:AT5G10300
Locus tag
AT5G10300
See related
Araport:AT5G10300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA METHYL ESTERASE 5; AtHNL; ATMES5; F18D22.70; F18D22_70; HNL; HYDROXYNITRILE LYASE; methyl esterase 5
Summary
Encodes a protein with R-selective hydroxynitrile lyase activity. It has similarity to the SABP2 methyl salicylate esterase from tobacco. This protein does not act on methyl IAA, methyl JA, MeSA, MeGA4, or MEGA9 in vitro.
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Genomic context

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See MES5 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
3
Sequence:
Chromosome: 5; NC_003076.8 (3239455..3240883)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene myb domain protein 92 Neighboring gene leucine-rich repeat transmembrane protein kinase family protein Neighboring gene EPIDERMAL PATTERNING FACTOR-like protein Neighboring gene ATP synthase subunit B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hydroxynitrile lyase defends Arabidopsis against Tetranychus urticae. Arnaiz A, et al. Plant Physiol, 2022 Aug 1. PMID 35474139, Free PMC Article
  2. A QM/MM study of the reaction mechanism of (R)-hydroxynitrile lyases from Arabidopsis thaliana (AtHNL). Zhu W, et al. Proteins, 2015 Jan. PMID 25052541
  3. Hydroxynitrile lyases with α/β-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms. Andexer JN, et al. Chembiochem, 2012 Sep 3. PMID 22851196, Free PMC Article
  4. Synthesis of (R)-β-nitro alcohols catalyzed by R-selective hydroxynitrile lyase from Arabidopsis thaliana in the aqueous-organic biphasic system. Fuhshuku K, et al. J Biotechnol, 2011 May 20. PMID 21439333
  5. A downstream mediator in the growth repression limb of the jasmonate pathway. Yan Y, et al. Plant Cell, 2007 Aug. PMID 17675405, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The catalytic mechanism of AtHNL was theoretically studied based on the recently obtained crystal structure in.
    Title: A QM/MM study of the reaction mechanism of (R)-hydroxynitrile lyases from Arabidopsis thaliana (AtHNL).
  2. Determined is the structure of the recently identified, R-selective HYDROXYNITRILE LYASE from Arabidopsis thaliana at a crystallographic resolution of 2.5 A.
    Title: Hydroxynitrile lyases with α/β-hydrolase fold: two enzymes with almost identical 3D structures but opposite enantioselectivities and different reaction mechanisms.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001343099.1
NM_121068.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mandelonitrile lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response to insect IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycoside catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
methyl esterase 5
NP_196592.1
  • methyl esterase 5 (MES5); CONTAINS InterPro DOMAIN/s: Alpha/beta hydrolase fold-1 (InterPro:IPR000073); BEST Arabidopsis thaliana protein match is: methyl esterase 1 (TAIR:AT2G23620.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    3239455..3240883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_121068.4 → NP_196592.1  methyl esterase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196592.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q93Z57, Q94AI5, Q9LFT6
    UniProtKB/TrEMBL
    A0A178U928, A0A5S9Y3I3, A0A654FZU5, A0A7G2F7A8
    Conserved Domains (1) summary
    PLN02211
    Location:3 → 250
    PLN02211; methyl indole-3-acetate methyltransferase

  2. NM_001343099.1 → NP_001332228.1  methyl esterase 5 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8BGG9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LFT6.1

Gene LinkOut

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