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2-Cys Prx B 2-cysteine peroxiredoxin B [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830517, updated on 7-Sep-2023

Summary

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Gene symbol
2-Cys Prx B
Gene description
2-cysteine peroxiredoxin B
Primary source
Araport:AT5G06290
Locus tag
AT5G06290
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
2-CYS PEROXIREDOXIN B; 2-cysteine peroxiredoxin B; 2CPB
Summary
Encodes a 2-Cys peroxiredoxin (2-Cys PrxB) that contains two catalytic Cys residues.
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Genomic context

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Location:
chromosome: 5
Exon count:
7
Sequence:
Chromosome: 5; NC_003076.8 (1919080..1921425)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene Putative lysine decarboxylase family protein Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene NDR1/HIN1-like 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Physiological relevance of plant 2-Cys peroxiredoxin overoxidation level and oligomerization status. Cerveau D, et al. Plant Cell Environ, 2016 Jan. PMID 26138759
  2. Redox-control of chlorophyll biosynthesis mainly depends on thioredoxins. Richter AS, et al. FEBS Lett, 2018 Sep. PMID 30076598
  3. Thermodynamics of the dimer-decamer transition of reduced human and plant 2-cys peroxiredoxin. Barranco-Medina S, et al. Biochemistry, 2008 Jul 8. PMID 18553980
  4. Divergent light-, ascorbate-, and oxidative stress-dependent regulation of expression of the peroxiredoxin gene family in Arabidopsis. Horling F, et al. Plant Physiol, 2003 Jan. PMID 12529539, Free PMC Article
  5. Thioredoxin-like2/2-Cys peroxiredoxin redox cascade supports oxidative thiol modulation in chloroplasts. Yoshida K, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104347, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 2-cysteine peroxiredoxins
    Title: Redox-control of chlorophyll biosynthesis mainly depends on thioredoxins.
  2. The oligomerization status of plant 2-Cys PRX does not exhibit important variation and is not tightly linked to the protein redox status upon physiologically relevant environmental constraints.
    Title: Physiological relevance of plant 2-Cys peroxiredoxin overoxidation level and oligomerization status.
  3. interaction of chloroplast 2-Cys peroxiredoxin with NADPH-thioredoxin reductase C (NTRC) and thioredoxin x
    Title: Molecular recognition in the interaction of chloroplast 2-Cys peroxiredoxin with NADPH-thioredoxin reductase C (NTRC) and thioredoxin x.
  4. 2-cysteine peroxoredoxins from Homo sapiens, Arabidopsis thaliana, and Pisum sativum as well as a carboxy-terminally truncated variant were subjected to isothermal titration calorimetry analysis.
    Title: Thermodynamics of the dimer-decamer transition of reduced human and plant 2-cys peroxiredoxin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001342875.1
NM_120712.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables peroxidase activity IDA
Inferred from Direct Assay
more info
  
enables peroxiredoxin activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin-dependent peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in apoplast HDA PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in stromule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
2-cysteine peroxiredoxin B
NP_568166.1
  • 2-cysteine peroxiredoxin B (2-Cys Prx B); FUNCTIONS IN: peroxiredoxin activity, antioxidant activity; INVOLVED IN: response to cold, defense response to bacterium; LOCATED IN: apoplast, stromule, chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peroxiredoxin, C-terminal (InterPro:IPR019479), Thioredoxin fold (InterPro:IPR012335), Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen (InterPro:IPR000866), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: Thioredoxin superfamily protein (TAIR:AT3G11630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    1919080..1921425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120712.4 → NP_568166.1  2-cysteine peroxiredoxin B [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_568166.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9C5R8, Q9FED5, Q9FNH9
    UniProtKB/TrEMBL
    A0A178ULP1, A0A654FYS1
    Conserved Domains (1) summary
    cd03015
    Location:82 → 255
    PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...

  2. NM_001342875.1 → NP_001331225.1  2-cysteine peroxiredoxin B [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178ULP1, A0A1P8BD74
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C5R8.3

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