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CEV1 Cellulose synthase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 830399, updated on 19-Feb-2025
Official Symbol
CEV1
Official Full Name
Cellulose synthase family protein
Primary source
TAIR:AT5G05170
Locus tag
AT5G05170
See related
Araport:AT5G05170
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCESA3; ATH-B; CELLULOSE SYNTHASE 3; CESA3; CONSTITUTIVE EXPRESSION OF VSP 1; ECTOPIC LIGNIFICATION 1; ELI1; ISOXABEN RESISTANT 1; ISOXABEN RESISTANT 1; IXR1; K2A11.4; K2A11_4; MRE1; multiple response expansion 1
Summary
Encodes a cellulose synthase isomer. CESA3 mutants have cellulose defect in the primary cell wall. Multiple lines of evidence suggest that CESA3, along with CESA1 and CESA6 are present in the same plasma membrane complex for cellulose biosynthesis. As inferred from the null role of secondary wall-type CesAs, included in a set of five primary wall-type CesAs that may support trichome cell wall thickening. The xylem cells in primary root have reduced cell expansion and higher than normal lignification.
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Location:
chromosome: 5
Exon count:
15
Sequence:
Chromosome: 5; NC_003076.8 (1530132..1535558, complement)

Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Transcription elongation factor (TFIIS) family protein Neighboring gene autophagy-related protein 18E Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene myosin heavy chain, striated protein Neighboring gene hypothetical protein (DUF3133) Neighboring gene ncRNA

Genomic Sequence:
NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The thanatos mutation in Arabidopsis thaliana cellulose synthase 3 (AtCesA3) has a dominant-negative effect on cellulose synthesis and plant growth. Daras G, et al. New Phytol, 2009. PMID 19645738
  2. The rotation of cellulose synthase trajectories is microtubule dependent and influences the texture of epidermal cell walls in Arabidopsis hypocotyls. Chan J, et al. J Cell Sci, 2010 Oct 15. PMID 20876662
  3. Super-resolution imaging illuminates new dynamic behaviors of cellulose synthase. Duncombe SG, et al. Plant Cell, 2022 Jan 20. PMID 34524465, Free PMC Article
  4. Structure of Arabidopsis CESA3 catalytic domain with its substrate UDP-glucose provides insight into the mechanism of cellulose synthesis. Qiao Z, et al. Proc Natl Acad Sci U S A, 2021 Mar 16. PMID 33729990, Free PMC Article
  5. Interaction between Autonomous and Microtubule Guidance Systems Controls Cellulose Synthase Trajectories. Chan J, et al. Curr Biol, 2020 Mar 9. PMID 32037093

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Super-resolution imaging illuminates new dynamic behaviors of cellulose synthase.
    Title: Super-resolution imaging illuminates new dynamic behaviors of cellulose synthase.
  2. Interaction between Autonomous and Microtubule Guidance Systems Controls Cellulose Synthase Trajectories.
    Title: Interaction between Autonomous and Microtubule Guidance Systems Controls Cellulose Synthase Trajectories.
  3. The results indicate that TRM4 is essential for microtubule array organization and therefore correct cellulose orientation in the SCE cells, as well as the establishment of the subsequent mucilage architecture.
    Title: TRM4 is essential for cellulose deposition in Arabidopsis seed mucilage by maintaining cortical microtubule organization and interacting with CESA3.
  4. The phenotypes observed in the trans-heterozygotes indicate that the mre1 and cev1 alleles of the AtCesA3 gene display intragenic complementation.
    Title: Two alleles of the AtCesA3 gene in Arabidopsis thaliana display intragenic complementation.
  5. The stoichiometry of the cellulose synthase catalytic subunits (CESAs) in the primary cell wall CSC was determined and CESA1, CESA3, and CESA6 are present in a 1:1:1 molecular ratio.
    Title: Catalytic subunit stoichiometry within the cellulose synthase complex.
  6. PI4K and PI3K are required for distinct steps in secretory and/or endocytic trafficking of CESA3.
    Title: Phosphatidylinositol 3-kinase and 4-kinase have distinct roles in intracellular trafficking of cellulose synthase complexes in Arabidopsis thaliana.
  7. computational findings on transmembrane helices (TMHs) 5 and 6 in three CESAs of Arabidopsis thaliana (AtCESA1, 3, and 6), the Atcesa3(ixr1-2) mutant, and a novel missense mutation in AtCESA1, are reported.
    Title: Computational and genetic evidence that different structural conformations of a non-catalytic region affect the function of plant cellulose synthase.
  8. The cell walls in the roots of these four AtCESA3 alleles contain different percentages of cellulose, and these percentages correlate with the lengths of the roots and cortex cells in these roots when grown on media containing high levels of sucrose.
    Title: Four alleles of AtCESA3 form an allelic series with respect to root phenotype in Arabidopsis thaliana.
  9. CESA1(A903V) and CESA3(T942I) have modified microfibril structure in terms of crystallinity and suggest that in plants, as in bacteria, crystallization biophysically limits polymerization.
    Title: Cellulose microfibril crystallinity is reduced by mutating C-terminal transmembrane region residues CESA1A903V and CESA3T942I of cellulose synthase.
  10. Data test that hypothesis using Arabidopsis plants expressing the cellulose synthase GFP-CESA3 and show that cellulose synthase trajectories do rotate over several hours.
    Title: The rotation of cellulose synthase trajectories is microtubule dependent and influences the texture of epidermal cell walls in Arabidopsis hypocotyls.
Submit: New GeneRIF Correction See all GeneRIFs (13)
Products Interactant Other Gene Complex Source Pubs Description

Homology

NM_120599.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables cellulose synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cellulose synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellulose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellulose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within lignin biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within plant-type primary cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant-type primary cell wall biogenesis TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within plant-type secondary cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plant-type secondary cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of carbohydrate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in plasmodesma HDA PubMed 
located_in trans-Golgi network HDA PubMed 
Preferred Names
Cellulose synthase family protein
NP_196136.1
  • CONSTITUTIVE EXPRESSION OF VSP 1 (CEV1); FUNCTIONS IN: cellulose synthase activity, transferase activity, transferring glycosyl groups; INVOLVED IN: primary cell wall biogenesis, cellulose biosynthetic process, defense response; LOCATED IN: Golgi apparatus, plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Cellulose synthase (InterPro:IPR005150), Zinc finger, RING-type (InterPro:IPR001841); BEST Arabidopsis thaliana protein match is: cellulose synthase 1 (TAIR:AT4G32410.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003076.8 Reference assembly

    Range
    1530132..1535558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_120599.4 → NP_196136.1  Cellulose synthase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_196136.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O48948, Q0WLU1, Q941L0, Q9FHK6
    UniProtKB/TrEMBL
    A0A178UN95, A0A384K963, A0A7G2F5X3, W8Q6G0
    Conserved Domains (1) summary
    PLN02638
    Location:1 → 1065
    PLN02638; cellulose synthase A (UDP-forming), catalytic subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q941L0.2

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