Format

Send to:

Choose Destination

KLRC4 killer cell lectin like receptor C4 [ Homo sapiens (human) ]

Gene ID: 8302, updated on 11-Jun-2021

Summary

Official Symbol
KLRC4provided by HGNC
Official Full Name
killer cell lectin like receptor C4provided by HGNC
Primary source
HGNC:HGNC:6377
See related
Ensembl:ENSG00000183542 MIM:602893
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NKG2F; NKG2-F
Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]
Expression
Broad expression in spleen (RPKM 6.6), lymph node (RPKM 3.0) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KLRC4 in Genome Data Viewer
Location:
12p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (10407384..10409757, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10559983..10562356, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2598 Neighboring gene KLRK1 antisense RNA 1 Neighboring gene KLRC4-KLRK1 readthrough Neighboring gene killer cell lectin like receptor K1 Neighboring gene killer cell lectin like receptor C3 Neighboring gene killer cell lectin like receptor C2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough KLRC4-KLRK1

Readthrough gene: KLRC4-KLRK1, Included gene: KLRK1

Homology

Clone Names

  • FLJ17759, FLJ78582

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NKG2-F type II integral membrane protein
Names
NK cell receptor F
NKG2-F-activating NK receptor
killer cell lectin-like receptor subfamily C, member 4
natual killer cell group 2-F

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013431.2NP_038459.1  NKG2-F type II integral membrane protein

    See identical proteins and their annotated locations for NP_038459.1

    Status: REVIEWED

    Source sequence(s)
    AJ001683
    Consensus CDS
    CCDS8624.1
    UniProtKB/Swiss-Prot
    O43908
    Related
    ENSP00000310216.1, ENST00000309384.2
    Conserved Domains (1) summary
    cl02432
    Location:120143
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    10407384..10409757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center